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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Cimetidine is a histamine H₂‑receptor antagonist that reduces gastric acid secretion by blocking H₂ receptors on parietal cells. It decreases basal and stimulated acid output and also inhibits several CYP450 isoenzymes, affecting drug metabolism. Its imidazole ring mediates high receptor affinity and enzyme interactions.
Benefits and Advantages
Used in gastric‑acid physiology research, H₂‑receptor pharmacology, CYP‑inhibition studies, drug–drug interaction modelling and ulcer‑pathogenesis investigations.
Side Effects and Risks
Risks include gynecomastia, galactorrhoea, CNS effects (confusion in elderly), hepatic enzyme changes and strong CYP‑mediated drug interactions. Handle with H₂‑blocker precautions.
Datasheet
| Molecular Formula | C10H16N6S |
|---|---|
| Molecular Weight | 252.34 g/mol |
| CAS Number | 51481-61-9 |
| Storage Condition | Preserve in tight, light resistant containers at controlled room temperatures. |
| Solubility | 5 mg/mL at 68 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | cimetidine; 51481-61-9; Ulcedin; Eureceptor; Gastromet |
| IUPAC/Chemical Name | 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine |
| InChl Key | AQIXAKUUQRKLND-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) |
| References | PubChem; ChemBL; FDA; |
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