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Product Description
Mechanism of Action
Cilazapril is an angiotensin‑converting enzyme (ACE) inhibitor administered as a prodrug converted to cilazaprilat. It inhibits ACE‑mediated conversion of angiotensin I to angiotensin II, reducing vasoconstriction, aldosterone secretion and sympathetic tone. This lowers systemic vascular resistance and improves endothelial function.
Benefits and Advantages
Used in RAAS‑pathway research, cardiovascular‑remodelling studies, hypertension models, endothelial‑function experiments and ACE‑inhibitor SAR investigations.
Side Effects and Risks
Risks include cough, hyperkalemia, hypotension, renal impairment, angioedema and fetal toxicity. Handle as a potent RAAS‑modulating compound.
Datasheet
| Molecular Formula | C22H24N2O5 |
|---|---|
| Molecular Weight | 417.5 g/mol |
| CAS Number | 88768-40-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Water (25 ºC) 0.5 g/100 mL |
| Purity | Purity information is available upon request (COA). |
| Synonym | cilazapril; 88768-40-5; Inhibace; Cilazapril anhydrous; Cilazaprilum |
| IUPAC/Chemical Name | (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid |
| InChl Key | HHHKFGXWKKUNCY-FHWLQOOXSA-N |
| InChl Code | InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1 |
| References | PubChem; ChemBL; FDA; |
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