About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Cilazapril is an angiotensinconverting enzyme (ACE) inhibitor administered as a prodrug converted to cilazaprilat. It inhibits ACEmediated conversion of angiotensin I to angiotensin II, reducing vasoconstriction, aldosterone secretion and sympathetic tone. This lowers systemic vascular resistance and improves endothelial function.
Benefits and Advantages
Used in RAASpathway research, cardiovascularremodelling studies, hypertension models, endothelialfunction experiments and ACEinhibitor SAR investigations.
Side Effects and Risks
Risks include cough, hyperkalemia, hypotension, renal impairment, angioedema and fetal toxicity. Handle as a potent RAASmodulating compound.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H24N2O5 |
|---|---|
| Molecular Weight | 417.5 g/mol |
| CAS Number | 88768-40-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Water (25 ºC) 0.5 g/100 mL |
| Purity | Purity information is available upon request (COA). |
| Synonym | cilazapril; 88768-40-5; Inhibace; Cilazapril anhydrous; Cilazaprilum |
| IUPAC/Chemical Name | (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid |
| InChl Key | HHHKFGXWKKUNCY-FHWLQOOXSA-N |
| InChl Code | InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1 |
| References | PubChem; ChemBL; FDA; |
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