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Product Description
Mechanism of Action
Chlorthialidone hydrochloride is a highly soluble salt form of chlorthalidone with identical mechanisms: inhibition of the distal‑tubular Na⁺/Cl⁻ symporter, reduced plasma volume, long‑acting antihypertensive effect and improved calcium retention. The HCl form improves formulation stability and aqueous handling.
Benefits and Advantages
Used in salt‑solubility PK studies, antihypertensive research, chronic diuresis modelling, NCC-transporter pharmacology and metabolic‑side‑effect comparisons across thiazide derivatives.
Side Effects and Risks
Risks include electrolyte depletion, insulin resistance, hyperuricemia, dizziness, muscle cramps and dehydration. Handle following diuretic‑class precautions.
Datasheet
| Molecular Formula | C14H11ClN2O4S |
|---|---|
| Molecular Weight | 338.76 g/mol |
| CAS Number | 77-36-1 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | chlorthalidone; 77-36-1; Chlortalidone; Phthalamudine; Hygroton |
| IUPAC/Chemical Name | 2-chloro-5-(3,4-dihydro-1,1-dioxo-2H-isoindol-2-yl)benzenesulfonamide |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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