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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Chlorpropamide is a first-generation sulfonylurea that stimulates insulin release from pancreatic β-cells. It binds to the SUR1 subunit of ATP-sensitive potassium (K_ATP) channels, causing closure of the channel, membrane depolarisation, opening of voltage-dependent calcium channels and insulin granule exocytosis. It has a long half-life, producing prolonged hypoglycaemic effects.
Benefits and Advantages
Used in diabetes-pathway modelling, K_ATP channel studies, β-cell physiology research, sulfonylurea SAR investigations, insulin-secretion assays and historical oral hypoglycaemic compound comparisons.
Side Effects and Risks
Risks include prolonged hypoglycaemia, flushing (especially with alcohol), water retention, hyponatraemia (SIADH), weight gain and allergic reactions. Handle with glucose-lowering agent precautions.
Datasheet
| Molecular Formula | C10H13ClN2O3S |
|---|---|
| Molecular Weight | 276.74 g/mol |
| CAS Number | 94-20-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 57 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | chlorpropamide; 94-20-2; Diabinese; Glucamide; Diabenese |
| IUPAC/Chemical Name | 1-(4-chlorophenyl)sulfonyl-3-propylurea |
| InChl Key | RKWGIWYCVPQPMF-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14) |
| References |
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