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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Chlorothiazide is a thiazide diuretic that inhibits the Na⁺/Cl symporter (NCC) in the distal convoluted tubule. This reduces sodium and chloride reabsorption, increasing diuresis and decreasing extracellular fluid volume. It also reduces calcium excretion, providing secondary benefits in calciumstone research.
Benefits and Advantages
Used in renalphysiology modelling, electrolytetransport studies, hypertension research, nephrolithiasis studies, NCCtransporter inhibition assays and diuretic SAR investigations.
Side Effects and Risks
Risks include hypokalemia, hyponatremia, hyperuricemia, hypotension, glucose intolerance and rare photosensitivity. Handle as a potent electrolytealtering compound.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C7H8ClN3O4S2 |
|---|---|
| Molecular Weight | 295.7 g/mol |
| CAS Number | 58-94-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 67.1 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | chlorothiazide; 58-94-6; Diuril; Chlorthiazide; Chlorothiazid |
| IUPAC/Chemical Name | 6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide |
| InChl Key | JBMKAUGHUNFTOL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13) |
| References |
3D Conformer.
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