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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Chlorothiazide is a thiazide diuretic that inhibits the Na⁺/Cl⁻ symporter (NCC) in the distal convoluted tubule. This reduces sodium and chloride reabsorption, increasing diuresis and decreasing extracellular fluid volume. It also reduces calcium excretion, providing secondary benefits in calcium‑stone research.
Benefits and Advantages
Used in renal‑physiology modelling, electrolyte‑transport studies, hypertension research, nephrolithiasis studies, NCC‑transporter inhibition assays and diuretic SAR investigations.
Side Effects and Risks
Risks include hypokalemia, hyponatremia, hyperuricemia, hypotension, glucose intolerance and rare photosensitivity. Handle as a potent electrolyte‑altering compound.
Datasheet
| Molecular Formula | C7H8ClN3O4S2 |
|---|---|
| Molecular Weight | 295.7 g/mol |
| CAS Number | 58-94-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 67.1 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | chlorothiazide; 58-94-6; Diuril; Chlorthiazide; Chlorothiazid |
| IUPAC/Chemical Name | 6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide |
| InChl Key | JBMKAUGHUNFTOL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13) |
| References |
3D Conformer.
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