CELECOXIB
Celecoxib is a COX‑2 inhibitor reducing pain and inflammation with lower GI risk than NSAIDs. Side effects include cardiovascular risk, edema, and dyspepsia.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Celecoxib is a selective cyclo‑oxygenase‑2 (COX‑2) inhibitor that reduces synthesis of pro‑inflammatory prostaglandins while sparing COX‑1–mediated gastric protection and platelet aggregation. It reduces inflammation, pain signalling and vascular prostaglandin‑driven responses through reversible COX‑2 blockade and downstream reduction of prostaglandin E₂.
Benefits and Advantages
Used in inflammatory‑pathway research, COX‑2 selectivity modelling, prostaglandin synthesis studies, tumour‑microenvironment investigations, pain‑modulation assays and NSAID SAR profiling. Also applied in angiogenesis‑inhibition and cytokine‑regulation research.
Side Effects and Risks
Risks include cardiovascular events, renal impairment, fluid retention, GI irritation (reduced vs non‑selective NSAIDs), and rare hypersensitivity. Handle with NSAID‑class precautions.
Datasheet
| Molecular Formula | C17H14F3N3O2S |
|---|---|
| Molecular Weight | 381.4 g/mol |
| CAS Number | 169590-42-5 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. |
| Solubility | Poorly soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | celecoxib; 169590-42-5; Celebrex; Celebra; Onsenal |
| IUPAC/Chemical Name | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide |
| InChl Key | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
