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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Product Description
Mechanism of action
Cefatrizine propionate is an orally bioavailable cephalosporin prodrug that is hydrolysed in vivo to the active antibiotic cefatrizine. The active moiety binds PBPs and inhibits cell-wall peptidoglycan crosslinking, leading to bactericidal effects against susceptible gram-positive and gram-negative organisms. The propionate ester enhances absorption and stability in the gastrointestinal tract.
Benefits and advantages
Used in oral cephalosporin pharmacokinetics research, prodrug-conversion studies, β-lactam SAR profiling, gram-negative susceptibility assays and formulation-optimisation experiments. It is useful for modelling intestinal ester hydrolysis and systemic delivery of cephalosporins.
Side effects and risks
Risks include allergic reactions, GI disturbances, dysbiosis and rare hepatic or haematological abnormalities. Standard β-lactam handling precautions should be followed.
Datasheet
| Molecular Formula | C22H24N6O6S2 |
|---|---|
| Molecular Weight | 548.59 g/mol |
| CAS Number | 65208-33-1 |
| Storage Condition | Store in a cool, dry place; protected from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| IUPAC/Chemical Name | Propan-2-yl (6R,7R)-7-{[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino}-3-(methylsulfanyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| References | PubChem; ChemBL; FDA substance registry; |
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