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Product Description
Mechanism of action
Carbidopa is a peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor that prevents the conversion of levodopa to dopamine outside the central nervous system. By inhibiting peripheral decarboxylation, it increases the fraction of levodopa reaching the brain, enhancing central dopamine replenishment while reducing peripheral dopaminergic side effects such as nausea and cardiovascular instability.
Benefits and advantages
Carbidopa is fundamental in Parkinson’s-disease research, dopaminergic-metabolism modelling, pharmacokinetic optimisation of levodopa therapy, enzyme-inhibition studies and blood–brain barrier transport investigations. It is a key tool for separating central from peripheral effects of dopamine precursors in experimental systems.
Side effects and risks
Risks include nausea, orthostatic hypotension, dyskinesia (via interaction with levodopa), psychiatric symptoms and rare haematologic or hepatic disturbances. Handle with enzyme-inhibitor precautions and avoid inhalation of fine powder.
Datasheet
| Molecular Formula | C10H14N2O4 |
|---|---|
| Molecular Weight | 226.23 g/mol |
| CAS Number | 113-92-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | carbidopa; 28860-95-9; Lodosyn; Carbidopa anhydrous; (S)-carbidopa |
| IUPAC/Chemical Name | (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid |
| InChl Key | TZFNLOMSOLWIDK-JTQLQIEISA-N |
| InChl Code | InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1 |
| References |
3D Conformer.
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