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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Butamirate is a centrally acting non-opioid antitussive that suppresses cough by modulating the medullary cough centre and inhibiting vagal afferent signalling. Unlike opioids, it lacks direct μ‑receptor activity and does not cause respiratory depression or dependence.
Benefits and advantages
Used in cough-reflex pathway studies, brainstem neurophysiology, vagal-afferent modulation research, antitussive SAR investigations and respiratory-control modelling. It is a reference compound for non-opioid central cough suppression.
Side effects and risks
Risks include dizziness, mild sedation, nausea and rare hypersensitivity. Handle under CNS-modulating compound safety guidelines.
Datasheet
| Molecular Formula | C24H37NO10 |
|---|---|
| Molecular Weight | 499.6 g/mol |
| CAS Number | 18109-81-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Butamirate citrate; 18109-81-4; Abbott 36581; HH 197; HH-197 |
| IUPAC/Chemical Name | 2-[2-(diethylamino)ethoxy]ethyl 2-phenylbutanoate;2-hydroxypropane-1,2,3-tricarboxylic acid |
| InChl Key | JVKMHUAWFDGPTF-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H29NO3.C6H8O7/c1-4-17(16-10-8-7-9-11-16)18(20)22-15-14-21-13-12-19(5-2)6-3;7-3(8)1-6(13,5(11)12)2-4(9)10/h7-11,17H,4-6,12-15H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) |
| References |
3D Conformer.
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