About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Buspirone is an anxiolytic agent that acts as a partial agonist at serotonin 5HTA receptors, reducing presynaptic serotonin release and modulating downstream serotonergic tone. It also exhibits mild dopamine D receptor affinity without producing sedation, dependence or major psychomotor impairment. The anxiolytic effect arises from modulation of limbic-system signalling rather than GABAergic pathways targeted by benzodiazepines.
Benefits and advantages
Used in anxiety-pathway research, serotonin-autoreceptor studies, limbic neurocircuit modelling, dopaminergicserotonergic interaction research and behavioural-pharmacology investigations. A key reference drug distinguishing non-sedative anxiolysis from GABA-mediated sedation.
Side effects and risks
Risks include dizziness, nausea, headache, restlessness, mild tachycardia and rare serotonin-related interactions. Handle as a CNS-active serotonergic compound.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C21H31N5O2 |
|---|---|
| Molecular Weight | 385.5 g/mol |
| CAS Number | 33386-08-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 5.88e-01 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | buspirone; 36505-84-7; Buspirona; Ansial; Buspironum |
| IUPAC/Chemical Name | 8-[4-(piperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride |
| InChl Key | QYUFABZPGFJGNE-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2 |
| References |
3D Conformer.
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