BUPARVAQUONE
Buparvaquone is a hydroxynaphthoquinone antiprotozoal that inhibits mitochondrial electron transport in Theileria species. Used mainly in veterinary medicine. Side effects may include injectionsite reactions and mild systemic discomfort. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Buparvaquone is a hydroxynaphthoquinone antiprotozoal agent structurally related to atovaquone. It inhibits the mitochondrial electron transport chain, targeting the cytochrome bc complex in protozoal pathogens, leading to ATP depletion and cell death.
Benefits and advantages
Used in protozoal-infection research, mitochondrial-electron-transport studies, veterinary-pharmacology modelling, quinone-antiprotozoal SAR studies and drug-resistance analyses.
Side effects and risks
Risks include hepatotoxicity, GI discomfort, hypersensitivity and photosensitivity. Handle under antimicrobial and quinone-compound safety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H28O3 |
|---|---|
| Molecular Weight | 326.4 g/mol |
| CAS Number | 88426-33-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Buparvaquone; 88426-33-9; Butalex; Buparvacuona; Buparvaquonum |
| IUPAC/Chemical Name | 3-[(4-tert-butylcyclohexyl)methyl]-4-hydroxynaphthalene-1,2-dione |
| InChl Key | NEGDTWQGGLJCTL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C21H26O3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,22H,8-12H2,1-3H3 |
| References |
3D Conformer.
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