About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Buformin is a biguanide class antihyperglycaemic agent structurally related to metformin and phenformin. It reduces hepatic gluconeogenesis, increases peripheral glucose uptake and enhances insulin sensitivity. It also influences AMPK activation and mitochondrial respiratory-chain function.
Benefits and advantages
Used in metabolic-disease research, AMPK-signalling studies, gluconeogenesis modelling, biguanide SAR analysis, mitochondrial function studies and diabetes drug-development. Its potency and distinct PK profile make it useful in comparisons among biguanides.
Side effects and risks
Risks include lactic acidosis (especially in renal impairment), GI upset, fatigue and metabolic acidosis. Handle under biguanide safety protocols with strict dose control.
Datasheet
| Molecular Formula | C6H16ClN5 |
|---|---|
| Molecular Weight | 193.68 g/mol |
| CAS Number | 1190-53-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | buformin hydrochloride; 1190-53-0; Buformine HCl; Buformin HCl; Panformin |
| IUPAC/Chemical Name | 2-butyl-1-(diaminomethylidene)guanidine;hydrochloride |
| InChl Key | KKLWSPPIRBIEOV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H |
| References |
3D Conformer.
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