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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Product Description
Mechanism of action
Bromouridine (5‑bromouridine, BrU) is a uridine analog incorporated into nascent RNA during transcription. It enables detection of newly synthesised RNA via immunoprecipitation or immunofluorescence using anti‑BrdU/BrU antibodies. Mechanistically, it acts as a metabolic RNA label without significantly altering transcriptional fidelity.
Benefits and advantages
Essential in transcription‑dynamics research, RNA‑turnover studies, metabolic‑labelling assays, gene‑expression timing analysis, nascent‑RNA mapping, and RNA‑processing pathway investigations.
Side effects and risks
Risks include cytotoxicity at high incorporation levels, mutagenic potential and skin/eye irritation. Handle under nucleoside‑analogue safety protocols with light protection.
Datasheet
| Molecular Formula | C9H11BrN2O6 |
|---|---|
| Molecular Weight | 323.10 g/mol |
| CAS Number | 957-75-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | 5-Bromouridine; 957-75-5; Uridine, 5-bromo-; bromouridine; 1-beta-Ribofuranosyl-5-bromo-uracil |
| IUPAC/Chemical Name | 5-bromo-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| InChl Key | AGFIRQJZCNVMCW-UAKXSSHOSA-N |
| InChl Code | InChI=1S/C9H11BrN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1 |
| References |
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