BROMERGOCRYPTINE
Bromergocryptine is a dopamine agonist used in Parkinsons disease, hyperprolactinemia, and acromegaly. Benefits include reduced prolactin and improved motor control. Side effects include nausea, hypotension, and headache. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Bromergocryptine is an ergotderived alkaloid exhibiting dopaminergic agonist activity, primarily at D receptors. It inhibits prolactin secretion via antagonism of pituitary lactotrophs and modulates central dopaminergic signalling. It also influences serotonergic and adrenergic pathways.
Benefits and advantages
Applied in endocrineresearch models (prolactin regulation), dopaminergic signalling studies, Parkinsonism investigations, pituitaryadenoma research and ergotalkaloid structureactivity analyses.
Side effects and risks
Risks include nausea, orthostatic hypotension, vasospasm, hallucinations, cardiacvalve fibrosis (high chronic exposure) and GI upset. Requires ergotalkaloid handling controls.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C32H40BrN5O5 |
|---|---|
| Molecular Weight | 654.6 g/mol |
| CAS Number | 25614-03-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 8.58e-02 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | bromocriptine; 25614-03-3; Bromoergocryptine; Bromocriptin; Bromergocryptine |
| IUPAC/Chemical Name | (6aR,9R)-5-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide |
| InChl Key | OZVBMTJYIDMWIL-AYFBDAFISA-N |
| InChl Code | InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
