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Product Description
Mechanism of action
Betaxolol is a highly selective β₁‑adrenergic receptor antagonist that reduces cardiac output by decreasing heart rate, contractility and renin release. Its β₁ selectivity minimises bronchoconstrictive effects compared with non‑selective beta‑blockers. Betaxolol also exhibits mild membrane‑stabilising activity and calcium‑channel–modulating effects, which contribute to reduced intraocular pressure when used in ocular formulations.
Benefits and advantages
Widely used in cardiovascular research, β₁‑receptor selectivity studies, intraocular‑pressure pharmacology, glaucoma models, renin–angiotensin regulation experiments and electrophysiological mapping of adrenergic signalling. A standard comparator for next‑generation cardioselective β‑blockers.
Side effects and risks
Risks include bradycardia, hypotension, fatigue, conduction abnormalities and rare bronchospasm. Handle with cardiovascular‑active compound precautions.
Datasheet
| Molecular Formula | C18H29NO3 |
|---|---|
| Molecular Weight | 307.4 g/mol |
| CAS Number | 63659-18-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | betaxolol; 63659-18-7; Betaxololum; SL 75212; O0ZR1R6RZ2 |
| IUPAC/Chemical Name | 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol |
| InChl Key | NWIUTZDMDHAVTP-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3 |
| References |
3D Conformer.
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