BENZONATATE
Benzonatate is a research-grade compound used in advanced pharmaceutical and biochemical studies. Chemical & Pharmacological Characteristics It is a lipophilic ester structurally related to local anesthetics, with formulation-sensitive stability and hydrolysis behavior. Mechanism of Action Benzonatate reduces sensory nerve excitability by inhibiting voltage-gated sodium channels in pulmonary stretch receptors. This suppresses afferent cough signaling; effects resemble local anesthetics and require careful dose control in experimental systems. It is primarily applied to investigate compound-specific mechanisms, physicochemical behavior, and analytical or formulation-relevant characteristics under controlled laboratory conditions.
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Product Description
Chemical & Pharmacological Characteristics
It is a lipophilic ester structurally related to local anesthetics, with formulation-sensitive stability and hydrolysis behavior.
Mechanism of Action
Benzonatate reduces sensory nerve excitability by inhibiting voltage-gated sodium channels in pulmonary stretch receptors.
This suppresses afferent cough signaling; effects resemble local anesthetics and require careful dose control in experimental systems.
Advanced Research Applications
- Sensory neuron electrophysiology studies
- Cough reflex pathway modeling
- Sodium channel modulation research
- Local anesthetic comparator assays
- Formulation stability assessment
Toxicodynamics & Cellular Hazard Spectrum
- CNS and cardiovascular toxicity at high exposure
- Narrow safety margin in biological systems
- Rapid toxicity upon improper exposure
- Neuronal suppression confounding endpoints
- Strict laboratory handling controls required
For expert laboratory research only – not intended for biological or therapeutic exposure.
Datasheet
| Molecular Formula | C30H53NO11 |
|---|---|
| Molecular Weight | 603.7 g/mol |
| CAS Number | 104-31-4 |
| Storage Condition | Store in tight, light-resistant container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. |
| Solubility | Soluble in most organic solvents except aliphatic hydrocarbons |
| Purity | Purity information is available upon request (COA). |
| Synonym | Benzonatate; 104-31-4; Benzononatine; Tessalon; Benzonatatum |
| IUPAC/Chemical Name | 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-(butylamino)benzoate |
| InChl Key | MAFMQEKGGFWBAB-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C30H53NO11/c1-3-4-9-31-29-7-5-28(6-8-29)30(32)42-27-26-41-25-24-40-23-22-39-21-20-38-19-18-37-17-16-36-15-14-35-13-12-34-11-10-33-2/h5-8,31H,3-4,9-27H2,1-2H3 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/7699; small-molecule |
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