BENZIODARONE
Benziodarone is a research-grade compound used in advanced pharmaceutical and biochemical studies. Chemical & Pharmacological Characteristics The presence of iodine increases molecular weight and lipophilicity, which can drive tissue partitioning and complicate solubility in aqueous systems. Formulation typically requires suitable co-solvents or surfactants to maintain stable exposure. Iodinated aromatics can present distinct metabolic and safety considerations due to halogenated scaffold persistence. It is primarily applied to investigate compound-specific mechanisms, physicochemical behavior, and analytical or formulation-relevant characteristics under controlled laboratory conditions.
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Product Description
Chemical & Pharmacological Characteristics
The presence of iodine increases molecular weight and lipophilicity, which can drive tissue partitioning and complicate solubility in aqueous systems. Formulation typically requires suitable co-solvents or surfactants to maintain stable exposure. Iodinated aromatics can present distinct metabolic and safety considerations due to halogenated scaffold persistence.
Mechanism of Action
A single definitive receptor mechanism is not consistently assigned across models. Reported effects are often interpreted as combined modulation of vascular signaling and metabolic pathways, with downstream changes in perfusion and tissue oxygenation.
In mechanistic R&D use, benziodarone is best treated as a comparative tool to examine how iodinated lipophilic scaffolds influence biodistribution, mitochondrial stress signatures, and oxidative metabolism markers under controlled exposure.
Advanced Research Applications
- Comparative vascular pharmacology and perfusion-related biomarker studies
- Biodistribution and tissue partitioning research for iodinated scaffolds
- Metabolic stability and halogenated aromatic biotransformation profiling
- Safety pharmacology panels focusing on hepatic and mitochondrial endpoints
- Analytical method development for iodinated compound quantification
Toxicodynamics & Cellular Hazard Spectrum
- Potential hepatic stress signatures in susceptible systems; monitor liver biomarkers
- Lipophilicity-driven accumulation and prolonged washout confounding kinetics
- Solubility limitations and aggregation artifacts; validate exposure levels
- Iodinated scaffold persistence may elevate long-term liability concerns
- Use PPE and controlled waste disposal for halogenated organics
For expert laboratory research only – not intended for biological or therapeutic exposure.
Datasheet
| Molecular Formula | C17H12I2O3 |
|---|---|
| Molecular Weight | 518.08 g/mol |
| CAS Number | 68-90-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | BENZIODARONE; 68-90-6; Amplivix; L 2329; Benziodaronum |
| IUPAC/Chemical Name | (2-ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodophenyl)methanone |
| InChl Key | CZCHIEJNWPNBDE-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H12I2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/6237; small-molecule |
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