AMMONIATED MERCURY
Ammoniated Mercury is a research-grade compound used in advanced pharmaceutical and biochemical studies. Chemical & Pharmacological Characteristics The material comprises mercury coordinated with ammonia-derived ligands, typically forming a poorly soluble inorganic complex. Its defining feature is strong affinity for sulfur-containing functional groups (protein and low-molecular-weight thiols), driving persistent binding in biological matrices. Limited solubility and tight binding can extend residence time once exposure occurs, complicating interpretation of recovery kinetics and emphasizing the need for strict exposure control. It is primarily applied to investigate compound-specific mechanisms,
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Product Description
Chemical & Pharmacological Characteristics
The material comprises mercury coordinated with ammonia-derived ligands, typically forming a poorly soluble inorganic complex. Its defining feature is strong affinity for sulfur-containing functional groups (protein and low-molecular-weight thiols), driving persistent binding in biological matrices. Limited solubility and tight binding can extend residence time once exposure occurs, complicating interpretation of recovery kinetics and emphasizing the need for strict exposure control.
Mechanism of Action
Toxicity is driven by high-affinity mercury-thiol interactions that irreversibly inhibit enzymes and disrupt protein structure. Binding to catalytic cysteines impairs core metabolic pathways, including antioxidant defense, mitochondrial respiration, and protein quality control, producing broad collapse of cellular homeostasis.
Mercury binding depletes glutathione and other thiol buffers, promoting oxidative stress with secondary damage to membranes, proteins, and nucleic acids. Mitochondrial dysfunction (electron transport disruption, ROS escalation, membrane potential loss) can trigger apoptosis or necrosis depending on dose and cell type, while inflammatory signaling may rise as a downstream consequence of redox imbalance and damage-associated pattern activation.
Advanced Research Applications
- Heavy-metal toxicology benchmarking and dose-response hazard mapping
- Mechanistic studies of thiol-reactive metal chemistry in biological matrices
- Mitochondrial toxicity and redox-collapse modeling (orthogonal ROS endpoints)
- Validation of mercury quantification assays and environmental monitoring methods
- Evaluation of chelation, sequestration, or detoxification strategies in vitro
Toxicodynamics & Cellular Hazard Spectrum
- Severe neurotoxicity and nephrotoxicity risks; cumulative tissue injury potential
- Glutathione depletion and oxidative stress escalation with broad macromolecular damage
- Mitochondrial shutdown/ROS runaway leading to apoptosis-necrosis spectrum activation
- High persistence due to protein binding; delayed toxicity and recovery confounding
- Strict hazardous waste requirements; mercury-specific containment and disposal
For expert laboratory research only – not intended for biological or therapeutic exposure.
Datasheet
| Molecular Formula | ClH2HgN |
|---|---|
| Molecular Weight | 252.07 g/mol |
| CAS Number | 10124-48-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | SOLUBILITY IN COLD WATER: 0.14 G/100 CC; SOLUBILITY IN HOT WATER: 100 G/100 CC (DECOMPOSES) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Ammoniated mercury; Mercuric amidochloride; 10124-48-8; Mercuric chloride, ammoniated; Mercury amide chloride |
| IUPAC/Chemical Name | azanide;mercury(2+);chloride |
| InChl Key | WRWRKDRWMURIBI-UHFFFAOYSA-M |
| InChl Code | InChI=1S/ClH.Hg.H2N/h1H;;1H2/q;+2;-1/p-1 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/3032553; small-molecule |
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