ACETARSOL
Acetarsol is an organoarsenical compound with antiparasitic and antimicrobial properties, historically used to treat infections such as trichomoniasis and amoebiasis. It interferes with parasitic enzymes. Benefits include broad activity. Risks include gastrointestinal upset, mucosal irritation, and potential arsenic toxicity, requiring careful monitoring.
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Product Description
Mechanism of action
Acetarsol is an aromatic arsenical compound with antiprotozoal and antifungal properties. It is thought to interfere with parasitic enzymes containing sulfhydryl groups, leading to inhibition of essential metabolic pathways and cell death. Historically it has been used in topical or suppository formulations for amoebiasis and certain mucosal infections.
Benefits and advantages
In selected indications, acetarsol can offer targeted treatment where resistance or intolerance to other agents limits options. Its local application allows high concentrations at the site of infection with relatively low systemic exposure when correctly formulated.
Side effects and risks
Because it contains arsenic, systemic absorption carries a risk of arsenic‑related toxicity, including neurotoxicity, hepatotoxicity, haematological changes and dermatological effects. Use has largely been replaced by safer alternatives in many regions. Any handling or formulation of acetarsol must therefore adhere to strict hazardous‑substance protocols, with appropriate protective equipment and waste management.
Professional use only. This substance is supplied exclusively to licensed companies and institutions.
Datasheet
| Molecular Formula | C8H10AsNO5 |
|---|---|
| Molecular Weight | 275.09 g/mol |
| CAS Number | 97-44-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Slightly soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | acetarsol; Acetarsone; 97-44-9; Acetphenarsine; Stovarsol |
| IUPAC/Chemical Name | (3-acetamido-4-hydroxyphenyl)arsonic acid |
| InChl Key | ODFJOVXVLFUVNQ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15) |
| References |
3D Conformer.
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