ACECLIDINE HCL
Aceclidine hydrochloride is a parasympathomimetic agent that stimulates muscarinic receptors, increasing aqueous humor outflow and lowering intraocular pressure. It is primarily used for glaucoma. Benefits include targeted action and suitability for long-term control. Possible side effects include eye irritation, blurred vision, headaches, and increased tearing, while systemic effects are uncommon.
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Product Description
Mechanism of action
Aceclidine hydrochloride is a direct‑acting muscarinic receptor agonist. When applied topically in the eye it stimulates the sphincter pupillae and ciliary muscles, causing miosis and increased aqueous humour outflow via the trabecular meshwork. This leads to reduced intra‑ocular pressure.
Benefits and advantages
Aceclidine has been used in the management of glaucoma and for producing miosis during ophthalmic procedures. Its local mechanism allows targeted reduction of intra‑ocular pressure without systemic beta‑blockade or carbonic anhydrase inhibition, making it an alternative option in specific clinical scenarios or combination therapy.
Side effects and risks
Local adverse effects may include ocular irritation, conjunctival hyperaemia, accommodative spasm and transient blurred vision. Systemic cholinergic effects such as headache, sweating or bradycardia are unlikely but possible if significant systemic absorption occurs. As an API, aceclidine should be handled under controlled conditions to avoid accidental exposure, particularly to the eyes.
Datasheet
| Molecular Formula | C9H16ClNO2 |
|---|---|
| Molecular Weight | 205.68 g/mol |
| CAS Number | 6109-70-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Freely soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Aceclidine hydrochloride; 6109-70-2; 1-azabicyclo[2.2.2]octan-3-yl acetate hydrochloride; 3-Acetoxyquinuclidine hydrochloride; Quinuclidin-3-yl acetate hydrochloride |
| IUPAC/Chemical Name | 1-azabicyclo[2.2.2]octan-3-yl acetate;hydrochloride |
| InChl Key | LWWSARSTZGNKGV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C9H15NO2.ClH/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3;1H |
| References |
3D Conformer.
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