ACEBUTOLOL
Acebutolol is a cardioselective beta‑blocker with intrinsic sympathomimetic activity, used to treat hypertension and cardiac arrhythmias. It reduces heart rate and myocardial oxygen demand, promoting cardiovascular stability. Benefits include effective blood pressure reduction and lower bronchoconstriction risk than non-selective beta‑blockers. Potential side effects include fatigue, dizziness, and mild gastrointestinal disturbances.
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Product Description
Mechanism of action
Acebubolol is a cardioselective beta‑1 adrenergic receptor blocker with partial agonist (intrinsic sympathomimetic) activity. By antagonising beta‑1 receptors in the heart, it reduces heart rate, myocardial contractility and cardiac output, leading to lowered blood pressure and decreased myocardial oxygen demand.
Benefits and advantages
Acebubolol is employed in the management of hypertension and certain cardiac arrhythmias when formulated as an oral beta‑blocker. Its relative beta‑1 selectivity offers advantages in patients where bronchospasm is a concern, and intrinsic sympathomimetic activity may reduce resting bradycardia and negative inotropic effects in some clinical contexts.
Side effects and risks
Adverse effects typical for beta‑blockers include bradycardia, fatigue, dizziness and cold extremities. In susceptible individuals, especially at higher doses, bronchospasm, worsening heart failure or conduction disturbances may occur. Abrupt withdrawal can precipitate rebound hypertension or angina. Handling of the API should follow appropriate occupational safety standards to minimise exposure.
Datasheet
| Molecular Formula | C18H28N2O4 |
|---|---|
| Molecular Weight | 336.4 g/mol |
| CAS Number | 37517-30-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | acebutolol; 37517-30-9; Acetobutolol; Acebutololo; Acebutololum |
| IUPAC/Chemical Name | N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide |
| InChl Key | GOEMGAFJFRBGGG-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23) |
| References |
3D Conformer.
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