PONATINIB HCL
Ponatinib HCl is a tyrosine kinase inhibitor targeting BCR‑ABL and resistant T315I mutations, used in chronic myeloid leukemia. Benefits include effective control of resistant disease. Side effects include hypertension, arterial thrombosis, pancreatitis, rash, myelosuppression, and hepatotoxicity.
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Product Description
Scientific Overview
PONATINIB HCL (ID 27186) is a research‑grade biochemical compound used for advanced analytical, mechanistic and structural studies. It is often applied in laboratory environments requiring precise molecular behaviour, controlled pathway modulation and high‑fidelity reproducibility. The compound interacts with multiple biochemical systems depending on formulation, cell type and experimental conditions.
Mechanism of Action
Although the exact mechanism may vary by experimental model, PONATINIB HCL typically exhibits activity involving:
- Enzymatic pathway modulation through reversible or irreversible interaction with catalytic sites
- Potential receptor‑level signaling effects influencing intracellular second messengers
- Alterations in redox balance and oxidative‑stress handling systems
- Mitochondrial functional modulation, including effects on ATP turnover and respiratory‑chain efficiency
- Influence on transcriptional behaviour, gene‑expression clusters and regulatory protein networks
- Possible interaction with cytoskeletal structures affecting cellular stability and mechanical signaling
These combined effects make the compound suitable for multi‑axis biochemical research.
Benefits and Applications
PONATINIB HCL is commonly used for:
- Pathway validation and mechanistic investigation
- Binding‑affinity studies and structural modelling
- Metabolic‑flux analysis and mitochondrial‑function profiling
- Redox and oxidative‑stress research environments
- Cytoskeletal and membrane‑dynamic studies
- Signal‑transduction mapping across diverse biological systems
Risks and Safety Considerations
Potential risks associated with laboratory exposure include:
- Oxidative imbalance or ROS accumulation
- Mitochondrial stress or functional suppression at high concentrations
- Unintended receptor or enzyme cross‑interaction
- Cytoskeletal destabilization or membrane disturbance
- Dose‑dependent cytotoxicity under prolonged exposure
Handle only with appropriate laboratory biosafety protocols.
Datasheet
| Molecular Formula | C29H27ClF3N5O·HCl |
|---|---|
| Molecular Weight | 569.0 g/mol |
| CAS Number | 1114544-31-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Ponatinib hydrochloride; 1114544-31-8; Iclusig; AP 24534 hydrochloride; AP24534 HCL |
| IUPAC/Chemical Name | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride |
| InChl Key | BWTNNZPNKQIADY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C29H27F3N6O.ClH/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37;/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39);1H |
| References |
3D Conformer.
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