Sirolimus (or rapamycin) is a macrolide compound used primarily to prevent organ rejection during transplants, treat lymphangioleiomyomatosis (a rare lung disease), and coat coronary stents.  Sirolimus’ primary immunosuppressive mechanism of action is its inhibition of the mechanistic Target Of Rapamycin (mTOR). It accomplishes this by inhibiting B cells and T cells’ activation by reducing their […]