Adapalene
Adapalene is a third-generation synthetic retinoid used in dermatological and acne-related research. It modulates retinoic acid receptor pathways, keratinocyte differentiation and inflammatory processes in the skin. Possible risks include dryness, redness, peeling, burning sensation, photosensitivity and local irritation. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Adapalene is a third-generation synthetic retinoid that binds retinoic acid receptors and modulates gene expression involved in keratinocyte differentiation and follicular epithelial turnover. It also has anti-inflammatory activity relevant to acne-related pathways.
Benefits and Advantages
Adapalene is used in dermatological formulation development, acne research, retinoid receptor studies and evaluation of topical delivery systems. Its chemical stability and receptor selectivity make it suitable for controlled product-development and comparative retinoid research.
Side Effects and Risks
Potential risks include dryness, erythema, peeling, burning sensation, photosensitivity and local irritation, especially during early exposure or when combined with irritating topical agents. Development and handling should follow appropriate dermatological, toxicological and regulatory standards.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C28H28O3 |
|---|---|
| Molecular Weight | 412.52 g/mol |
| CAS Number | 106685-40-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Soluble in DMSO; limited aqueous solubility. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Adapalene; CD271; Differin; 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid |
| IUPAC/Chemical Name | 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylic acid |
| InChl Key | LZCDAPDGXCYOEH-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30) |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/60164; small-molecule |
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