GC376
GC376 is a peptidomimetic inhibitor of viral 3C-like proteases, including coronavirus main protease research models. It can block protease-mediated polyprotein processing required for viral replication. The compound is used in antiviral screening and enzyme assays, with risks including bioactivity, cytotoxicity and unknown safety outside controlled research. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
GC376 is a peptidomimetic protease inhibitor that targets viral 3C-like proteases, including coronavirus main protease models. It forms a reversible covalent interaction with the catalytic cysteine in the protease active site, preventing cleavage of viral polyproteins required for replication.
Benefits and Advantages
The compound is valuable in antiviral screening, protease-activity assays, structure-activity studies and development of broad-spectrum 3CLpro or Mpro inhibitor scaffolds. Its well-defined target profile supports enzymatic, cellular and formulation-relevant research under controlled conditions.
Side Effects and Risks
Risks include bioactivity against protease-dependent systems, possible cellular toxicity, assay-specific interference and unknown safety margins outside research use. It should be handled using suitable laboratory controls and not used for therapeutic exposure without full regulatory qualification.
Professional use only. Supplied exclusively for qualified pharmaceutical, analytical or laboratory environments.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C21H30N3NaO8S |
|---|---|
| Molecular Weight | 507.50 g/mol |
| CAS Number | 1416992-39-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Soluble in DMSO; solubility depends on solvent and conditions. |
| Purity | Purity information is available upon request (COA). |
| Synonym | GC-376; GC376; GC376 sodium; GC-376 sodium salt |
| IUPAC/Chemical Name | sodium;[(2S)-2-[[2-(phenylmethoxycarbonylamino)-4-methylpentanoyl]amino]-3-(2-oxopyrrolidin-3-yl)propanoyl]oxymethanesulfinate |
| InChl Key | BSPJDKCMFIPBAW-JPBGFCRCSA-M |
| InChl Code | InChI=1S/C21H31N3O8S.Na/c1-13(2)10-16(24-21(28)32-12-14-6-4-3-5-7-14)19(26)23-17(20(27)33(29,30)31)11-15-8-9-22-18(15)25;/h3-7,13,15-17,20,27H,8-12H2,1-2H3,(H,22,25)(H,23,26)(H,24,28)(H,29,30,31);/q;+1/p-1/t15?,16-,17-,20?;/m0./s1 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/71481119; small-molecule |
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