AMOBARBITAL SODIUM
Amobarbital Sodium is a research-grade compound used in advanced pharmaceutical and biochemical studies. Chemical & Pharmacological Characteristics Salt formation enhances formulation flexibility compared with the free compound, particularly for aqueous preparations. Pharmacodynamic behavior is consistent with amobarbital, with dose-dependent CNS depression and a barbiturate class safety profile. Regulatory constraints may apply depending on jurisdiction. It is primarily applied to investigate compound-specific mechanisms, physicochemical behavior, and analytical or formulation-relevant characteristics under controlled laboratory conditions.
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Product Description
Chemical & Pharmacological Characteristics
Salt formation enhances formulation flexibility compared with the free compound, particularly for aqueous preparations. Pharmacodynamic behavior is consistent with amobarbital, with dose-dependent CNS depression and a barbiturate class safety profile. Regulatory constraints may apply depending on jurisdiction.
Mechanism of Action
Amobarbital sodium potentiates GABAA receptor-mediated inhibition by increasing chloride influx and promoting neuronal hyperpolarization. This reduces excitability at the circuit level and can produce sedative-hypnotic or anesthetic-like states depending on exposure.
At elevated exposures, suppression of respiratory drive and cardiovascular reflexes may occur. In vivo protocols should include continuous monitoring, while in vitro studies should account for broad network suppression that can mask more subtle mechanistic signals.
Advanced Research Applications
- Rapid-onset sedation/anesthesia modeling with controlled aqueous dosing
- CNS safety pharmacology and comparative GABAergic liability profiling
- Receptor and network electrophysiology studies requiring soluble barbiturate dosing
- Benchmark compound for formulation and delivery research in CNS models
- Translational studies linking exposure to sedation and respiratory endpoints
Toxicodynamics & Cellular Hazard Spectrum
- High risk of respiratory depression and profound CNS suppression at high dose
- Dependence/tolerance phenomena with repeated exposure in biological systems
- Behavioral endpoint confounding due to generalized suppression
- Controlled substance regulatory requirements for storage and documentation
- Use strict dosing controls and ethical monitoring in animal models
For expert laboratory research only – not intended for biological or therapeutic exposure.
Datasheet
| Molecular Formula | C11H17N2NaO3 |
|---|---|
| Molecular Weight | 248.25 g/mol |
| CAS Number | 64-43-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Amobarbital sodium (JAN/USP); RefChem:1076932; AMOBARBITAL SODIUM; Amytal sodium; 64-43-7 |
| IUPAC/Chemical Name | sodium 5-ethyl-5-(3-methylbutyl)-4,6-dioxo-1H-pyrimidin-2-olate |
| InChl Key | BNHGKKNINBGEQL-UHFFFAOYSA-M |
| InChl Code | InChI=1S/C11H18N2O3.Na/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/23689390; small-molecule |
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