AMMONIUM GLYCYRRHIZINATE
Ammonium Glycyrrhizinate is a research-grade compound used in advanced pharmaceutical and biochemical studies. Chemical & Pharmacological Characteristics Salt formation can improve handling and apparent solubility relative to the free acid. The molecule is amphiphilic and may bind nonspecifically to proteins and membranes, affecting free concentration in complex media. Biological activity can be influenced by metabolic conversion to related aglycones in systems with relevant enzymatic capacity, which should be considered when extrapolating between in vitro and in vivo observations. It is primarily applied to investigate compound-specific
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Product Description
Chemical & Pharmacological Characteristics
Salt formation can improve handling and apparent solubility relative to the free acid. The molecule is amphiphilic and may bind nonspecifically to proteins and membranes, affecting free concentration in complex media. Biological activity can be influenced by metabolic conversion to related aglycones in systems with relevant enzymatic capacity, which should be considered when extrapolating between in vitro and in vivo observations.
Mechanism of Action
Mechanistic activity is pleiotropic rather than single-target. Reported effects include modulation of inflammatory signaling networks and stress-response pathways, with downstream changes in mediator production and cellular activation states. Membrane-associated interactions may influence receptor clustering and barrier properties in epithelial systems.
A central mechanistic theme is interaction with 11β-hydroxysteroid dehydrogenase systems, altering local glucocorticoid activity and thereby shaping immune output. Because endocrine modulation can indirectly shift multiple pathways, dose-ranging and orthogonal endpoints are recommended to avoid over-attribution to a single signaling node.
Advanced Research Applications
- Inflammation and immunomodulation studies (multi-pathway response profiling)
- Endocrine-immune cross-talk research involving local glucocorticoid regulation
- Barrier biology and epithelial stress models where membrane effects are relevant
- Formulation compatibility and solubilization studies leveraging amphiphilicity
- Comparator compound in natural-product pharmacology and mechanistic screening
Toxicodynamics & Cellular Hazard Spectrum
- Mineralocorticoid-like effects in sensitive systems (sodium retention, hypokalemia risk)
- Nonspecific binding and assay interference due to amphiphilic properties
- Dose-dependent cellular stress at high exposure; interpretability window required
- Potential pH/solubility variability across buffers; document formulation conditions
- Use appropriate PPE; avoid unintended biological exposure in handling
For expert laboratory research only – not intended for biological or therapeutic exposure.
Datasheet
| Molecular Formula | C42H65NO16 |
|---|---|
| Molecular Weight | 840.0 g/mol |
| CAS Number | 53956-04-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | AMMONIUM GLYCYRRHIZINATE; Ammonium glycyrrhizate; 53956-04-0; Glycamil; Monoammonium glycyrrhizinate |
| IUPAC/Chemical Name | (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid;azane |
| InChl Key | ILRKKHJEINIICQ-OOFFSTKBSA-N |
| InChl Code | InChI=1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/62074; small-molecule |
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