About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
LEMBOREXANT (ID 32275) demonstrates a high‑granularity biochemical interaction profile spanning catalytic‑domain modulation, multi‑layer signalling interference, mitochondrial‑network recalibration, redox‑state restructuring, ion‑flux redistribution, membrane‑electrochemical modulation, cytoskeletal‑architecture remodelling and transcription‑factor axis reprogramming. Its molecular topology supports interactions with catalytic residues, allosteric regulatory surfaces, transmembrane helices, hydrophobic receptor pockets, nucleotide‑binding cavities, redox-buffer modules and polymeric scaffolding proteins—enabling broad influence across metabolic, genomic, electrophysiological and structural regulatory networks.
Mechanistically, LEMBOREXANT may reshape phosphorylation‑flow geometry across ERK/MAPK/JNK/p38 cascades, modulate PI3K–AKT survival‑pathway architecture, alter G‑protein coupling logic, redistribute Ca²⁺ microdomains, shift IP₃/DAG signal amplitude, and recalibrate cAMP–PKA oscillatory behaviour. Mitochondrial effects include ETC‑complex rebalancing, ATP/ADP flux modulation, ROS‑threshold displacement, mitochondrial‑membrane potential polarity shifts and ER–mitochondria bidirectional stress‑signal integration.
Advanced Research Applications
- Kinome‑scale catalytic‑cascade interference and pathway reconstruction
- Ultra‑resolution receptor/ligand docking and conformational‑transition modelling
- UPR/ER‑stress, mitophagy, autophagy and oxidative‑stress crosstalk research
- Deep multi‑omics network reconstruction (RNA‑seq, metabolomics, proteomics, phosphoproteomics)
- Cytoskeletal tension‑mapping, polymer turnover and mechano‑signalling analytics
- Apoptosis, necroptosis, ferroptosis, pyroptosis and parthanatos modelling
- Machine‑learning SAR/QSAR pipelines for predictive molecular optimisation
Toxicodynamics & Hazard Spectrum
- Rapid ROS accumulation and antioxidant‑buffer system collapse
- Mitochondrial fragmentation, membrane‑potential failure or ETC inhibition
- Severe Na⁺/K⁺/Ca²⁺ ion‑homeostasis disruption
- Cytoskeletal depolymerisation, actin/tubulin instability and loss of cellular mechanics
- Membrane‑integrity failure and lipid‑bilayer thinning
- NF‑κB, STAT and IRF inflammatory‑axis hyperactivation
- Engagement of multi‑axis programmed‑cell‑death pathways
- Epigenetic drift across methylation/acetylation domains
For expert laboratory research only — not intended for biological or therapeutic exposure.
Datasheet
| Molecular Formula | C22H20F2N4O2 |
|---|---|
| Molecular Weight | 410.4 g/mol |
| CAS Number | 1369764-02-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Lemborexant; 1369764-02-2; Dayvigo; E-2006; E2006 |
| IUPAC/Chemical Name | cis-(1R,2S)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)cyclopropane-1-carboxamide |
| InChl Key | MUGXRYIUWFITCP-PGRDOPGGSA-N |
| InChl Code | InChI=1S/C22H20F2N4O2/c1-13-19(11-25-14(2)27-13)30-12-22(15-4-3-5-16(23)8-15)9-18(22)21(29)28-20-7-6-17(24)10-26-20/h3-8,10-11,18H,9,12H2,1-2H3,(H,26,28,29)/t18-,22+/m0/s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
