TRIPTORELIN

Triptorelin is a GnRH agonist suppressing gonadal hormone production, used in prostate cancer, endometriosis, and puberty suppression. Side effects include hot flashes, libido changes, bone loss, and injectionsite reactions. Only GMP materials will be supplied, logistics all according to GDP.

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Product Description


Mechanism of Action

TRIPTORELIN demonstrates multilayer biochemical influence across signalling hierarchies, catalyticdomain regulation, mitochondrialnetwork energetics, iongradient stability, membrane electrochemistry, redox equilibrium and transcriptionfactor axis alignment. Its molecular topology enables interaction with catalytic residues, allosteric nodes, hydrophobic receptor microdomains, transmembrane helices, redoxbuffer matrices and cytoskeletal scaffolds, resulting in widespectrum modulation across metabolic, structural, electrophysiological and genomic systems.

Mechanistically, TRIPTORELIN may remodel phosphorylation flux across MAPK/ERK/JNK/p38 pathways, reshape PI3KAKT survival topology, modify Gprotein coupling dynamics, reorganise Ca²⁺ signalling microdomains, influence IP/DAG cascade geometry and adjust cAMPPKA amplitude distributions. Mitochondrial impacts include ETCcomplex rebalancing, ATP/ADP turnover pattern shifts, ROSthreshold displacement, membranepotential polarity modulation and ERmitochondrial stresscrosstalk regulation.

Advanced

  • Kinomescale interference mapping and catalyticcascade simulation
  • Highresolution docking and conformationaltransition modelling
  • UPR/ERstress, autophagymitophagy and organellenetwork integration research
  • Multiomics regulatory reconstruction (RNAseq, phosphoproteomics, metabolomics, proteomics)
  • Cytoskeletal tensionmapping and polymerturnover analysis
  • Cellfate simulations (apoptosis, necroptosis, ferroptosis, parthanatos)
  • Machinelearning SAR/QSAR predictive optimisation

Toxicodynamics & Hazard Profile

  • Accelerated ROS accumulation & antioxidantbuffer saturation
  • Mitochondrial fragmentation or ETCaxis destabilisation
  • Severe Na⁺/K⁺/Ca²⁺ ionic-flux dysregulation
  • Cytoskeletal collapse & membrane-integrity failure
  • Inflammatoryaxis hyperactivation (NF-κB, STAT, IRF pathways)
  • Activation of multiaxis programmed-cell-death pathways
  • Epigenetic methylation/acetylation drift

For expert laboratory research only not intended for biological or therapeutic exposure.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C64H82N18O13

Molecular Weight

1311.4 g/mol

CAS Number

57773-63-4

Storage Condition

Piperazine must be stored to avoid contact with oxidizers (such as perchlorates, peroxides, permanganates, chlorates, and nitrates) since violent reactions occur. . Sources of ignition such as smoking and open flames are prohibited where piperazine is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Store in tightly closed containers in a cool, well vented area away form oxidizers. Where possible, automatically transfer material from drums or other storage containers to process containers. Metal containers involving the transfer of this chemical should be grounded and bonded. Wherever this chemical is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings.

Solubility

Very soluble (NTP, 1992)

Purity

Purity information is available upon request (COA).

Synonym

TRIPTORELIN; 57773-63-4; Triptoreline; Triptorelina; Arvekap

IUPAC/Chemical Name

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

InChl Key

VXKHXGOKWPXYNA-PGBVPBMZSA-N

InChl Code

InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1

References

https://pubchem.ncbi.nlm.nih.gov/compound/25074470;

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