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Product Description
Mechanism of Action
TOCILIZUMAB (ID 27692) exerts multi‑axis biochemical modulation involving enzymatic‑cascade interference, receptor‑mediated signalling adjustment, oxidative‑stress balancing, mitochondrial‑respiratory modulation, ion‑channel behaviour influence, cytoskeletal‑architecture modification and transcription‑factor regulatory alignment. Its molecular topology supports potential interaction with catalytic residues, allosteric microdomains, membrane‑anchored receptor systems and intracellular signalling scaffolds. These interactions affect phosphorylation circuits, Ca²⁺ signalling, IP₃/DAG turnover, cAMP regulation, ATP flux and cellular redox‑state stability.
Benefits & Applications
- Receptor–ligand interaction and docking studies
- Kinase/catalytic pathway profiling
- Mitochondrial ATP/ROS functional modelling
- Multi‑omics integration research
- Cytoskeletal and membrane‑dynamics analysis
- Apoptosis, autophagy and survival‑pathway investigations
- SAR/QSAR modelling and molecular optimisation
Risks & Side Effects
- ROS accumulation and oxidative‑stress imbalance
- Mitochondrial overload or ETC suppression
- Ion‑channel destabilisation (Ca²⁺/Na⁺/K⁺)
- Cytoskeletal disruption and membrane integrity loss
- Dose‑dependent cytotoxicity
- Inflammatory cascade activation
Datasheet
| Molecular Formula | C6428H9976N1716O2018S44 |
|---|---|
| Molecular Weight | 148000.0 g/mol |
| CAS Number | 375823-41-9 |
| Storage Condition | Store at 28°C |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | RefChem:1072364; 5-(2-(4-Hydroxyphenyl)Ethenyl)Benzene-1,3-Diol; 133294-37-8; 5-[2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol; 1,3-Benzenediol, 5-[(1Z)-2-(4-hydroxyphenyl)ethenyl]- |
| IUPAC/Chemical Name | AntiIL6 receptor monoclonal antibody |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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