THIORIDAZIN

Thioridazine is a phenothiazine antipsychotic blocking dopamine receptors. Side effects include QT prolongation, sedation, anticholinergic effects, weight gain, and extrapyramidal symptoms. Only GMP materials will be supplied, logistics all according to GDP.

SKU: 4361ea2d03e3 Category: Tag:

Product Description


Mechanism of Action

THIORIDAZIN exerts multiaxis biochemical modulation involving enzymaticcascade interference, receptormediated signalling adjustment, oxidativestress balancing, mitochondrialrespiratory modulation, ionchannel behaviour influence, cytoskeletalarchitecture modification and transcriptionfactor regulatory alignment. Its molecular topology supports potential interaction with catalytic residues, allosteric microdomains, membraneanchored receptor systems and intracellular signalling scaffolds. These interactions affect phosphorylation circuits, Ca²⁺ signalling, IP/DAG turnover, cAMP regulation, ATP flux and cellular redoxstate stability.

Benefits & Applications

  • Receptorligand interaction and docking studies
  • Kinase/catalytic pathway profiling
  • Mitochondrial ATP/ROS functional modelling
  • Multiomics integration research
  • Cytoskeletal and membranedynamics analysis
  • Apoptosis, autophagy and survivalpathway investigations
  • SAR/QSAR modelling and molecular optimisation

Risks & Side Effects

  • ROS accumulation and oxidativestress imbalance
  • Mitochondrial overload or ETC suppression
  • Ionchannel destabilisation (Ca²⁺/Na⁺/K⁺)
  • Cytoskeletal disruption and membrane integrity loss
  • Dosedependent cytotoxicity
  • Inflammatory cascade activation

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C21H26N2S2

Molecular Weight

370.6 g/mol

CAS Number

50-52-2

Storage Condition

Store in tight, light-resistant container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity.

Solubility

Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance.

Purity

Purity information is available upon request (COA).

Synonym

thioridazine; 50-52-2; Mellaril; Thioridazin; Mellerette

IUPAC/Chemical Name

10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine

InChl Key

KLBQZWRITKRQQV-UHFFFAOYSA-N

InChl Code

InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3

References

https://pubchem.ncbi.nlm.nih.gov/compound/5452;

3D Conformer.

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