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Product Description
Mechanism of Action
TAMSULOSIN HYDROCHLORIDE (ID 27561) exhibits a highly distributed biochemical activity matrix spanning multi‑axis signalling disruption, enzymatic‑cascade interference, mitochondrial‑network recalibration, cytoskeletal remodelling, redox‑system modulation, ion‑flux redistribution and transcription‑factor pathway realignment. Its conformational topology enables interaction with catalytic cores, allosteric domains, transmembrane helices, hydrophobic receptor cavities, nucleotide‑binding pockets and multiprotein scaffolding structures. This generates system‑wide modulation across metabolic, genomic, structural and electrophysiological domains.
At the signalling level, TAMSULOSIN HYDROCHLORIDE may reshape phosphorylation gradients, modify propagation dynamics across MAPK/ERK/JNK/p38 axes, alter PI3K–AKT survival signalling, shift G‑protein coupling states, recalibrate intracellular Ca²⁺ microdomains, and modulate IP₃/DAG and cAMP‑PKA signalling amplitudes. Mitochondrial effects include ETC‑complex rebalancing, ATP‑turnover adjustment, ROS‑leakage threshold modulation and membrane‑potential polarity shifts. Its multi‑node regulation enables deep experimental interrogation of stress‑adaptation pathways and metabolic‑response thresholds.
High‑Resolution Research Applications
- Ultra‑scale kinome interference mapping & catalytic‑cascade simulation
- High‑fidelity receptor–ligand docking & conformational‑flow modelling
- Organelle cross‑talk modelling (UPR, mitochondrial/ER stress, mitophagy dynamics)
- Multi‑omics regulatory‑network reconstruction (RNA‑seq, metabolomics, proteomics, phosphoproteomics)
- Advanced cytoskeletal biomechanics (actin/tubulin turnover, tension‑mapping)
- Cell‑fate modelling across apoptosis, necroptosis, ferroptosis, parthanatos & autophagic flux axes
- AI‑enhanced SAR/QSAR molecular‑performance prediction
Toxicodynamics & Hazard Profile
- Accelerated ROS accumulation & antioxidant‑system saturation
- Mitochondrial fragmentation or ETC‑chain destabilisation
- Severe Ca²⁺/Na⁺/K⁺ ionic‑flux dysregulation
- Cytoskeletal depolymerisation & loss of mechanical integrity
- Membrane damage, permeability shifts & lipid‑bilayer thinning
- Inflammatory overactivation via NF‑κB, STAT & IRF signalling
- Multiple programmed‑cell‑death pathway activation
- Epigenetic distortions (methylation drift, acetylation imbalance)
For expert laboratory research only — not intended for biological exposure.
Datasheet
| Molecular Formula | C20H29ClN2O5S |
|---|---|
| Molecular Weight | 445.0 g/mol |
| CAS Number | 106463-17-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | TAMSULOSIN HYDROCHLORIDE; 106463-17-6; Tamsulosin HCl; Pradif; Harnal |
| IUPAC/Chemical Name | 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide;hydrochloride |
| InChl Key | ZZIZZTHXZRDOFM-XFULWGLBSA-N |
| InChl Code | InChI=1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1 |
| References |
3D Conformer.
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