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Product Description
Mechanism of Action
SULFISOXAZOLE (ID 27532) exhibits an expansive biochemical activity architecture integrating multi‑directional signalling modulation, catalytic‑pathway interference, mitochondrial‑network recalibration, ion‑flux reorganisation, cytoskeletal remodelling, membrane‑dynamics alteration and transcription‑factor axis redistribution. Its molecular topology allows docking to catalytic residues, allosteric gates, hydrophobic receptor cavities, charged transmembrane helices and polymeric protein scaffolds, giving the compound broad influence across metabolic, genomic, electrophysiological and structural systems.
At the signalling level, SULFISOXAZOLE may perturb phosphorylation gradients, alter ERK/JNK/MAPK propagation velocities, reorganise PI3K–AKT survival‑pathway bias, shift G‑protein coupling efficiency, regulate Ca²⁺ microdomains, reshape IP₃/DAG secondary‑messenger maps and influence cAMP‑PKA amplitude dynamics. Mitochondrially, it may modify membrane‑potential polarity, adjust ETC complex activation ratios, reshape ATP/ADP turnover behaviour and alter ROS leakage thresholds.
High‑Precision Research Applications
- Deep kinome interference mapping and signalling‑cascade simulations
- High‑resolution docking, ligand‑stability prediction & conformational flow analysis
- Mitochondrial stress modelling & organelle cross‑talk dynamics
- UPR/ER‑stress and integrated autophagy–mitophagy pathway analysis
- Multi‑omics regulatory‑network reconstruction (transcriptome, phosphoproteome, metabolome)
- Actin/tubulin turnover modelling and cytoskeletal force‑distribution mapping
- Cell‑fate mapping across apoptosis, necroptosis, ferroptosis and parthanatos
- Machine‑learning SAR/QSAR pipelines for advanced molecular optimisation
Toxicodynamics & Cellular Hazard Spectrum
- ROS surge and collapse of antioxidant‑buffer systems
- Mitochondrial fragmentation or ETC‑chain suppression
- Severe ionic‑flux destabilisation including Ca²⁺ overload
- Cytoskeletal disassembly & membrane‑integrity breakdown
- Hyperactivation of NF‑κB, STAT and IRF inflammatory axes
- Induction of programmed‑cell‑death pathways
- Epigenetic drift affecting methylation, acetylation and chromatin compaction
For expert laboratory use only — not intended for biological exposure.
Datasheet
| Molecular Formula | C11H13N3O3S |
|---|---|
| Molecular Weight | 267.31 g/mol |
| CAS Number | 127-69-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 72.5 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | sulfisoxazole; Sulfafurazole; 127-69-5; Sulphafurazole; Sulfafurazol |
| IUPAC/Chemical Name | 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide |
| InChl Key | NHUHCSRWZMLRLA-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3 |
| References |
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