SULFAMETHOXYPYRIDAZINE (SMP)
Sulfamethoxypyridazine (SMP) is a sulfonamide inhibiting bacterial folate synthesis, used in veterinary and research contexts. Side effects include GI upset, hypersensitivity, and renal crystallization. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
SULFAMETHOXYPYRIDAZINE (SMP) exhibits an expansive biochemical activity architecture integrating multidirectional signalling modulation, catalyticpathway interference, mitochondrialnetwork recalibration, ionflux reorganisation, cytoskeletal remodelling, membranedynamics alteration and transcriptionfactor axis redistribution. Its molecular topology allows docking to catalytic residues, allosteric gates, hydrophobic receptor cavities, charged transmembrane helices and polymeric protein scaffolds, giving the compound broad influence across metabolic, genomic, electrophysiological and structural systems.
At the signalling level, SULFAMETHOXYPYRIDAZINE (SMP) may perturb phosphorylation gradients, alter ERK/JNK/MAPK propagation velocities, reorganise PI3KAKT survivalpathway bias, shift Gprotein coupling efficiency, regulate Ca²⁺ microdomains, reshape IP/DAG secondarymessenger maps and influence cAMPPKA amplitude dynamics. Mitochondrially, it may modify membranepotential polarity, adjust ETC complex activation ratios, reshape ATP/ADP turnover behaviour and alter ROS leakage thresholds.
HighPrecision
- Deep kinome interference mapping and signallingcascade simulations
- Highresolution docking, ligandstability prediction & conformational flow analysis
- Mitochondrial stress modelling & organelle crosstalk dynamics
- UPR/ERstress and integrated autophagymitophagy pathway analysis
- Multiomics regulatorynetwork reconstruction (transcriptome, phosphoproteome, metabolome)
- Actin/tubulin turnover modelling and cytoskeletal forcedistribution mapping
- Cellfate mapping across apoptosis, necroptosis, ferroptosis and parthanatos
- Machinelearning SAR/QSAR pipelines for advanced molecular optimisation
Toxicodynamics & Cellular Hazard Spectrum
- ROS surge and collapse of antioxidantbuffer systems
- Mitochondrial fragmentation or ETCchain suppression
- Severe ionic-flux destabilisation including Ca²⁺ overload
- Cytoskeletal disassembly & membrane-integrity breakdown
- Hyperactivation of NF-κB, STAT and IRF inflammatory axes
- Induction of programmed-cell-death pathways
- Epigenetic drift affecting methylation, acetylation and chromatin compaction
For expert not intended for biological exposure.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C11H12N4O3S |
|---|---|
| Molecular Weight | 280.3 g/mol |
| CAS Number | 80-35-3 |
| Storage Condition | Store at 2-8°C |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | sulfamethoxypyridazine; 80-35-3; Sulphamethoxypyridazine; Midicel; Sulfapyridazine |
| IUPAC/Chemical Name | 4-amino-N-(3-methoxy-4-pyridyl)benzenesulfonamide |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
