About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
SUCCIMER – DMSA exhibits a broad and highcomplexity biochemical activity spectrum, modulating hierarchical signalling cascades, deep enzymatic networks, mitochondrial functional architecture, cytoskeletal integrity, transcriptionfactor coordination and multiaxis stressresponse systems. Its molecular conformation supports interaction with catalytic pockets, allosteric microdomains, transmembrane helices, regulatory scaffolds, ionchannel architectures and redoxbuffering systems, producing wideranging effects across metabolic, genomic, structural and electrophysiological layers.
Mechanistically, SUCCIMER – DMSA may alter phosphorylation topologies, reshape signallingcascade propagation (ERK, JNK, MAPK, PI3KAKT), amplify or suppress secondmessenger concentrations (Ca²⁺, cAMP, IP, DAG), modify mitochondrial membrane polarity, shift ATP/ADP cycling behaviour, regulate ROSleakage thresholds and influence global metabolic flux distribution. Its capacity to integrate signals from cytosolic, organellebound and membraneanchored proteins makes it suitable for advanced mechanistic interrogation.
HighLevel
- Deep kinomemapping & systemslevel pathwayinterference analysis
- Structural docking, ligandstability modelling & conformational dynamics
- Mitochondrialstress analysis including ETC complex modelling
- UPR, ERstress & integrated autophagy/mitophagy evaluation
- Multiomics network reconstruction (RNAseq, phosphoproteomics, metabolomics)
- Membranedynamics and cytoskeletal mechanotransduction studies
- Advanced cellfate modelling across apoptosis, necroptosis & ferroptosis axes
- Predictive SAR/QSAR pipelines using machinelearning optimisation
Toxicodynamics & Cellular Risk Spectrum
- Rapid ROS escalation & antioxidant-system saturation
- Mitochondrial fragmentation or ETC suppression
- Severe ionic-flux dysregulation (Ca²⁺, Na⁺, K⁺)
- Cytoskeletal collapse & membrane-integrity compromise
- Inflammatory upregulation (NF-κB, STAT, IRF)
- Activation of programmed-cell-death pathways
- Epigenetic drift involving methylation & acetylation instability
For expert not for biological or therapeutic exposure.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C4H6O4S2 |
|---|---|
| Molecular Weight | 182.2 g/mol |
| CAS Number | 304-55-2 |
| Storage Condition | Store at 2-8°C |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | 2,3-Dimercaptosuccinic acid; Dimercaptosuccinic acid; 2418-14-6; Suximer; 2,3-Dimercaptobutanedioic acid |
| IUPAC/Chemical Name | 2,3-dimercaptosuccinic acid |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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