STREPTOMYCIN
Streptomycin is an aminoglycoside antibiotic inhibiting the 30S ribosomal subunit, used for tuberculosis and severe gramnegative infections. Side effects include ototoxicity, nephrotoxicity, dizziness, and neuromuscular blockade. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
STREPTOMYCIN exhibits a broad and highcomplexity biochemical activity spectrum, modulating hierarchical signalling cascades, deep enzymatic networks, mitochondrial functional architecture, cytoskeletal integrity, transcriptionfactor coordination and multiaxis stressresponse systems. Its molecular conformation supports interaction with catalytic pockets, allosteric microdomains, transmembrane helices, regulatory scaffolds, ionchannel architectures and redoxbuffering systems, producing wideranging effects across metabolic, genomic, structural and electrophysiological layers.
Mechanistically, STREPTOMYCIN may alter phosphorylation topologies, reshape signallingcascade propagation (ERK, JNK, MAPK, PI3KAKT), amplify or suppress secondmessenger concentrations (Ca²⁺, cAMP, IP, DAG), modify mitochondrial membrane polarity, shift ATP/ADP cycling behaviour, regulate ROSleakage thresholds and influence global metabolic flux distribution. Its capacity to integrate signals from cytosolic, organellebound and membraneanchored proteins makes it suitable for advanced mechanistic interrogation.
HighLevel
- Deep kinomemapping & systemslevel pathwayinterference analysis
- Structural docking, ligandstability modelling & conformational dynamics
- Mitochondrialstress analysis including ETC complex modelling
- UPR, ERstress & integrated autophagy/mitophagy evaluation
- Multiomics network reconstruction (RNAseq, phosphoproteomics, metabolomics)
- Membranedynamics and cytoskeletal mechanotransduction studies
- Advanced cellfate modelling across apoptosis, necroptosis & ferroptosis axes
- Predictive SAR/QSAR pipelines using machinelearning optimisation
Toxicodynamics & Cellular Risk Spectrum
- Rapid ROS escalation & antioxidant-system saturation
- Mitochondrial fragmentation or ETC suppression
- Severe ionic-flux dysregulation (Ca²⁺, Na⁺, K⁺)
- Cytoskeletal collapse & membrane-integrity compromise
- Inflammatory upregulation (NF-κB, STAT, IRF)
- Activation of programmed-cell-death pathways
- Epigenetic drift involving methylation & acetylation instability
For expert not for biological or therapeutic exposure.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C21H39N7O12 |
|---|---|
| Molecular Weight | 581.6 g/mol |
| CAS Number | 57-92-1 |
| Storage Condition | Store dry powder under controlled room temperature 15 deg to 30 °C (59 deg to 86 °F). |
| Solubility | White to light gray or pale buff powder; faint amine-like odor; solubility in mg/mL at about 28 °C: water greater than 20; methanol 0.85; ethanol 0.30; isopropanol 0.01; petroleum ether 0.015; carbon tetrachloride 0.035; ether 0.035, Practically insoluble in chloroform. /Streptomycin sesquisulfate/ |
| Purity | Purity information is available upon request (COA). |
| Synonym | streptomycin; Strepcen; Gerox; Streptomycine; Agrimycin |
| IUPAC/Chemical Name | 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine |
| InChl Key | UCSJYZPVAKXKNQ-HZYVHMACSA-N |
| InChl Code | InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1 |
| References |
3D Conformer.
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