POLYHEXAMETHYLENE BIGUANIDE
Polyhexamethylene biguanide (PHMB) is a broadspectrum antimicrobial that disrupts microbial membranes and DNA. It is used in wound care, disinfectants, and contactlens solutions. Side effects include irritation, dryness, allergic reactions, and rare severe inflammatory responses in sensitive individuals. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Scientific Overview
POLYHEXAMETHYLENE BIGUANIDE is a researchgrade biochemical compound used for advanced analytical, mechanistic and structural studies. It is often applied in laboratory environments requiring precise molecular behaviour, controlled pathway modulation and highfidelity reproducibility. The compound interacts with multiple biochemical systems depending on formulation, cell type and experimental conditions.
Mechanism of Action
Although the exact mechanism may vary by experimental model, POLYHEXAMETHYLENE BIGUANIDE typically exhibits activity involving:
- Enzymatic pathway modulation through reversible or irreversible interaction with catalytic sites
- Potential receptorlevel signaling effects influencing intracellular second messengers
- Alterations in redox balance and oxidativestress handling systems
- Mitochondrial functional modulation, including effects on ATP turnover and respiratorychain efficiency
- Influence on transcriptional behaviour, geneexpression clusters and regulatory protein networks
- Possible interaction with cytoskeletal structures affecting cellular stability and mechanical signaling
These combined effects make the compound suitable for multiaxis biochemical research.
Benefits and Applications
POLYHEXAMETHYLENE BIGUANIDE is commonly used for:
- Pathway validation and mechanistic investigation
- Bindingaffinity studies and structural modelling
- Metabolicflux analysis and mitochondrialfunction profiling
- Redox and oxidativestress research environments
- Cytoskeletal and membranedynamic studies
- Signaltransduction mapping across diverse biological systems
Risks and Safety Considerations
Potential risks associated with laboratory exposure include:
- Oxidative imbalance or ROS accumulation
- Mitochondrial stress or functional suppression at high concentrations
- Unintended receptor or enzyme crossinteraction
- Cytoskeletal destabilization or membrane disturbance
- Dosedependent cytotoxicity under prolonged exposure
Handle only with appropriate laboratory biosafety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C8H17N5Cl·(n) |
|---|---|
| Molecular Weight | 205.06 g/mol |
| CAS Number | 27083-27-8 |
| Storage Condition | Store at 2-8°C |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | 5,6-Dichloro-1,2,3-benzothiadiazole; 23620-85-1; WL-19255; DTXSID40178297; RefChem:101131 |
| IUPAC/Chemical Name | Poly(hexamethylene biguanide) hydrochloride |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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