PHENYLEPHRINE HCL
Phenylephrine HCl is an alpha1 agonist causing vasoconstriction, used as a decongestant and to increase blood pressure during anesthesia. Side effects include hypertension, headache, anxiety, reflex bradycardia, and insomnia; excessive use can cause rebound congestion. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
PHENYLEPHRINE HCL demonstrates a broad, multilayer biochemical activity profile affecting enzymedriven catalytic pathways, receptorregulated signalling systems, mitochondrial bioenergetics, redoxstate equilibrium, ionchannel behaviour, cytoskeletal integrity and transcriptionfactor regulatory networks. Its structural features indicate potential interactions with catalytic residues, allosteric protein domains, membranebound receptors and intracellular signalling intermediates, enabling influence over phosphorylation kinetics, Ca²⁺/cAMP/IP/DAGmediated secondmessenger systems, ATP turnover, ROS buffering and mitochondrial respiratorychain performance.
Depending on concentration and biological conditions, PHENYLEPHRINE HCL may modulate metabolic flux distribution, alter mitochondrial membrane potential, influence chromatin accessibility, impact vesicular trafficking dynamics and reshape geneexpression patterns relevant to survival, inflammation, apoptosis, autophagy, metabolic adaptation and redoxstress response.
Benefits and Advantages
This compound is widely used across advanced biochemical, pharmacological and mechanistic research domains, including:
- Receptorligand interaction studies and affinitymapping
- Enzymekinetic pathway deconstruction and catalyticdomain profiling
- Mitochondrialfunction analysis and ATPflux/oxidativestress modelling
- Multiomics integration (transcriptomics, metabolomics, proteomics, phosphoproteomics)
- Cytoskeletalstructure and membranedynamics research
- Autophagy, apoptosis, necroptosis and ferroptosis signalling investigations
- SAR (structureactivity relationship) profiling and compoundoptimisation workflows
- Pharmacodynamic modelling, thresholdactivation mapping and doseresponse scaling
Side Effects and Risks
Laboratoryobserved or predicted risks include:
- Oxidative imbalance and excessive ROS accumulation
- Mitochondrial overload or respiratorychain suppression
- Dysregulation of Na⁺/K⁺/Ca²⁺ ionchannel homeostasis
- Unintended receptor crosstalk or inhibitory interference
- Cytoskeletal destabilisation and membrane-integrity disruption
- Dosedependent cytotoxicity with apoptosis/autophagy activation
- Transcriptional instability or epigenetic disturbance
- Inflammatory signalling activation via NF-κB, MAPK or JNK pathways
Use strictly within controlled laboratory environments under appropriate biosafety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C9H13NO2·HCl |
|---|---|
| Molecular Weight | 203.66 g/mol |
| CAS Number | 61-76-7 |
| Storage Condition | Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), unless otherwise specified by manufacturer. Store in a tight, light-resistant container if not more than 15 mL size. Protect from freezing. |
| Solubility | greater than or equal to 100 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | PHENYLEPHRINE HYDROCHLORIDE; 61-76-7; Phenylephrine HCl; Biomydrin; Mydfrin |
| IUPAC/Chemical Name | 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride |
| InChl Key | OCYSGIYOVXAGKQ-FVGYRXGTSA-N |
| InChl Code | InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
