PERHIXILEN MALEATE
Perindopril arginine is a salt form of perindopril with similar ACE-inhibitory effects but different pharmacokinetic characteristics. It provides long-lasting blood pressure reduction and cardiovascular protection. Side effects include dry cough, headache, hyperkalemia, worsening renal function, and rare angioedema, necessitating caution in susceptible individuals.
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Product Description
Mechanism of Action
PERHIXILEN MALEATE (ID 27072) demonstrates a multidimensional biochemical activity pattern, affecting enzyme‑regulated catalytic networks, receptor‑mediated intracellular signalling, mitochondrial respiratory pathways, oxidative‑stress regulation, ion‑channel behaviour, cytoskeletal mechanics and transcription‑factor network modulation. Structural evidence suggests potential interactions with catalytic residues, allosteric domains, transmembrane protein complexes, regulatory scaffolds and intracellular signalling intermediates. These interactions allow PERHIXILEN MALEATE to influence phosphorylation kinetics, second‑messenger signalling (Ca²⁺, cAMP, IP₃, DAG), redox‑buffering systems, ATP turnover rates and mitochondrial membrane‑potential stability.
Depending on experimental conditions, PERHIXILEN MALEATE may alter metabolic flux distribution, cytoskeletal tension, vesicular transport efficiency, chromatin‑accessibility patterns and gene‑expression networks related to stress responses, inflammation, apoptosis, autophagy and metabolic adaptation.
Benefits and Advantages
This compound is widely used across high‑resolution biochemical and pharmacological research areas, including:
- Receptor–ligand interaction analysis and affinity‑mapping
- Detailed enzyme‑kinetics profiling and catalytic‑pathway evaluation
- Mitochondrial‑dynamics studies, ATP‑flux modelling and oxidative‑stress research
- Integrated multi‑omics applications (transcriptomics, metabolomics, proteomics, phosphoproteomics)
- Cytoskeletal and membrane‑mechanics modelling
- Apoptosis, necroptosis, ferroptosis and autophagy signalling pathway studies
- SAR (structure–activity relationship) and molecular‑optimisation pipelines
- Mechanistic pharmacodynamic modelling and threshold‑activation experiments
Side Effects and Risks
Laboratory‑observed risks include:
- Oxidative‑stress imbalance and ROS overproduction
- Mitochondrial overload or suppression of respiratory‑chain complexes
- Dysregulation of Na⁺/K⁺/Ca²⁺ transport and ion‑channel behaviour
- Unintended receptor cross‑talk or inhibitory interference
- Cytoskeletal destabilisation and membrane‑integrity compromise
- Dose‑dependent cytotoxicity leading to apoptosis or autophagy
- Transcriptional instability or inflammatory signalling activation (NF‑κB, JNK, MAPK)
Use exclusively under controlled laboratory conditions with strict biosafety procedures.
Datasheet
| Molecular Formula | C19H35N·C4H2O4 |
|---|---|
| Molecular Weight | 325.44 g/mol |
| CAS Number | 128-62-1 |
| Storage Condition | Store at 2-8°C |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Gnoscopine; 6035-40-1; RefChem:1086139; 10421-76-8; Nascopine |
| IUPAC/Chemical Name | 2-(2,2-diethylpropyl)cyclohexanol maleate |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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