PENICILLIN V POTASSIUM
Penimepicycline is a combination of penicillin and tetracycline derivatives that inhibits bacterial cell-wall formation and protein synthesis, broadening antimicrobial coverage. It is used for mixed infections where such coverage is needed. Side effects include gastrointestinal upset, photosensitivity, candidiasis, and allergic reactions, including cross-sensitivity in penicillin- or tetracycline-allergic patients. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
PENICILLIN V POTASSIUM demonstrates a multidimensional biochemical activity pattern, affecting enzymeregulated catalytic networks, receptormediated intracellular signalling, mitochondrial respiratory pathways, oxidativestress regulation, ionchannel behaviour, cytoskeletal mechanics and transcriptionfactor network modulation. Structural evidence suggests potential interactions with catalytic residues, allosteric domains, transmembrane protein complexes, regulatory scaffolds and intracellular signalling intermediates. These interactions allow PENICILLIN V POTASSIUM to influence phosphorylation kinetics, secondmessenger signalling (Ca²⁺, cAMP, IP, DAG), redoxbuffering systems, ATP turnover rates and mitochondrial membranepotential stability.
Depending on experimental conditions, PENICILLIN V POTASSIUM may alter metabolic flux distribution, cytoskeletal tension, vesicular transport efficiency, chromatinaccessibility patterns and geneexpression networks related to stress responses, inflammation, apoptosis, autophagy and metabolic adaptation.
Benefits and Advantages
This compound is widely used across highresolution biochemical and pharmacological research areas, including:
- Receptorligand interaction analysis and affinitymapping
- Detailed enzymekinetics profiling and catalyticpathway evaluation
- Mitochondrialdynamics studies, ATPflux modelling and oxidativestress research
- Integrated multiomics applications (transcriptomics, metabolomics, proteomics, phosphoproteomics)
- Cytoskeletal and membranemechanics modelling
- Apoptosis, necroptosis, ferroptosis and autophagy signalling pathway studies
- SAR (structureactivity relationship) and molecularoptimisation pipelines
- Mechanistic pharmacodynamic modelling and thresholdactivation experiments
Side Effects and Risks
Laboratoryobserved risks include:
- Oxidativestress imbalance and ROS overproduction
- Mitochondrial overload or suppression of respiratorychain complexes
- Dysregulation of Na⁺/K⁺/Ca²⁺ transport and ionchannel behaviour
- Unintended receptor crosstalk or inhibitory interference
- Cytoskeletal destabilisation and membrane-integrity compromise
- Dosedependent cytotoxicity leading to apoptosis or autophagy
- Transcriptional instability or inflammatory signalling activation (NF-κB, JNK, MAPK)
Use exclusively under controlled laboratory conditions with strict biosafety procedures.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C16H17KN2O5S |
|---|---|
| Molecular Weight | 388.5 g/mol |
| CAS Number | 132-98-9 |
| Storage Condition | Commercially available … penicillin V potassium tablets and powders for oral suspension or solution should be stored in tight containers at 15-30 °C. Following reconstitution, penicillin V potassium oral solutions should be refrigerated at 2-8 °C and any unused solution should be discarded after 14 days. |
| Solubility | greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Penicillin V potassium; Penicillin V potassium salt; 132-98-9; PENICILLIN VK; Antibiocin |
| IUPAC/Chemical Name | potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| InChl Key | HCTVWSOKIJULET-LQDWTQKMSA-M |
| InChl Code | InChI=1S/C16H18N2O5S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1 |
| References |
3D Conformer.
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