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Product Description
Mechanism of Action
OXYMETHOLONE exhibits a multidimensional biochemical activity profile involving modulation of enzyme-catalyzed pathways, receptor-mediated intracellular signaling, ion-channel regulation, mitochondrial bioenergetics, oxidative-stress balancing, membrane dynamics, and transcription-factor orchestration. Its molecular configuration allows high-affinity interaction with catalytic residues, allosteric domains, regulatory scaffolds, and signaling intermediates, influencing phosphorylation cycles, secondmessenger flux (Ca²⁺, cAMP, IP, DAG), ROS equilibrium, ATP synthesis, and mitochondrial respiratory-chain regulation.
Depending on dose, exposure duration, and cell type, OXYMETHOLONE can modify chromatin accessibility, metabolic flux routing, vesicular trafficking, cytoskeletal structure, and gene-expression clusters associated with survival, inflammation, apoptosis, autophagy, and metabolic adaptation.
Benefits and Advantages
Due to its consistent mechanistic behavior, this compound is utilized in advanced research, including:
- Receptorligand interaction studies and affinity modeling
- Highresolution enzyme kinetics and catalytic-pathway deconstruction
- Mitochondrial ATPflux assays and oxidativestress system modeling
- Multiomics profiling (transcriptomics, proteomics, metabolomics, phosphoproteomics)
- Cytoskeletal and membranedynamics exploration
- Apoptosis, ferroptosis, necroptosis, and autophagy pathway analysis
- Structureactivity relationship (SAR) investigations and compound optimization
- Pharmacodynamic modeling, mechanistic doseresponse scaling, and pathway benchmarking
Side Effects and Risks
Potential laboratory risks include:
- Oxidativestress imbalance and ROS accumulation
- Mitochondrial overload or respiratory-chain suppression
- Ionchannel dysregulation affecting Ca²⁺/Na⁺/K⁺ homeostasis
- Unintended receptor crossactivation or pathway inhibition
- Cytoskeletal destabilization and membrane-integrity disruption
- Dose-dependent cytotoxicity (apoptotic or autophagic induction)
- Transcriptional or epigenetic instability under prolonged exposure
- Activation of inflammatory signaling networks (NF-κB, JNK, p38 MAPK)
Use strictly in controlled laboratory environments with appropriate biosafety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C21H32O3 |
|---|---|
| Molecular Weight | 332.5 g/mol |
| CAS Number | 434-07-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 73 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | oxymetholone; 434-07-1; Anasteron; Protanabol; Anapolon |
| IUPAC/Chemical Name | (2Z,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-2-(hydroxymethylidene)-10,13,17-trimethyl-1,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one |
| InChl Key | ICMWWNHDUZJFDW-DHODBPELSA-N |
| InChl Code | InChI=1S/C21H32O3/c1-19-11-13(12-22)18(23)10-14(19)4-5-15-16(19)6-8-20(2)17(15)7-9-21(20,3)24/h12,14-17,22,24H,4-11H2,1-3H3/b13-12-/t14-,15+,16-,17-,19-,20-,21-/m0/s1 |
| References |
3D Conformer.
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