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Product Description
Mechanism of Action
NORTRIPTYLINE HCL exhibits a complex and multipathway biochemical activity pattern that may involve modulation of enzymeregulated catalytic cascades, receptormediated intracellular signalling, mitochondrial bioenergetics, redoxstate homeostasis, membranepotential stabilisation, and transcriptionfactor regulatory networks. Structural properties suggest possible interactions with catalytic residues, allosteric binding pockets, regulatory scaffolding proteins, transmembrane receptors and intracellular signalling intermediates. These mechanisms allow NORTRIPTYLINE HCL to influence phosphorylationdephosphorylation cycles, secondmessenger systems (Ca²⁺, cAMP, IP, DAG), ROS buffering dynamics, ATP synthesis efficiency and the structural organisation of cytoskeletal components.
Depending on concentration and biological context, NORTRIPTYLINE HCL may shift metabolic routing, alter calcium flux, affect vesicular transport, reshape transcriptomic output and modify mitochondrial respiratorychain performance, contributing to its broad experimental applicability.
Benefits and Advantages
This compound is frequently used in advanced biochemical, pharmacological and mechanistic research areas, including:
- Receptorligand interaction profiling and affinitymapping studies
- Enzymekinetic characterisation and catalyticpathway modelling
- Mitochondrialfunction assays, ATPflux analysis and oxidativestress modelling
- Transcriptomics, proteomics, metabolomics and phosphoproteomics investigations
- Cytoskeletaldynamics studies involving actin/tubulin regulation and membranemechanics research
- Apoptosis, autophagy, ferroptosis and necroptosis pathway explorations
- Structureactivity relationship (SAR) development and molecularperformance optimisation
- Pharmacodynamic threshold modelling and doseresponse curve definition
Side Effects and Risks
Laboratoryobserved or theoretically predicted risks include:
- Redox imbalance, ROS accumulation and oxidativestress sensitisation
- Mitochondrial overload or suppression of respiratorychain complexes
- Disruption of ionchannel homeostasis (Na⁺/K⁺/Ca²⁺)
- Unintended receptor crossactivation or inhibition
- membrane-integrity compromise and cytoskeletal destabilisation
- Dosedependent cytotoxicity, apoptosis or excessive autophagy
- Transcriptional pathway destabilisation or inflammatory activation (NF-κB, JNK, MAPK)
Prolonged exposure or excessive dosing may trigger metabolic collapse, transcriptional rewiring or epigenetic instability. Use solely in controlled laboratory environments under strict biosafety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C19H21N·HCl |
|---|---|
| Molecular Weight | 299.8 g/mol |
| CAS Number | 894-71-3 |
| Storage Condition | Store at 20 deg to 25 °C (68 deg to 77 °F) |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Nortriptyline hydrochloride; 894-71-3; Nortriptyline Hcl; Aventyl hydrochloride; NSC-169453 |
| IUPAC/Chemical Name | N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride |
| InChl Key | SHAYBENGXDALFF-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H |
| References |
3D Conformer.
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