NALORPHINE
Nalorphine is an early opioid antagonist with partial agonist activity that can reverse opioid‑induced respiratory depression while producing some analgesia and dysphoria. It acts mainly at μ and κ receptors. Side effects include agitation, nausea, vomiting, anxiety, blood pressure changes, and acute withdrawal symptoms in opioid‑dependent individuals, limiting its modern clinical use.
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Product Description
Mechanism of Action
NALORPHINE (ID 26822) exhibits a multi‑vector biochemical action pattern, influencing enzymatic cascades, receptor‑mediated signalling, intracellular ion behaviour, mitochondrial oxidative dynamics and transcriptional regulatory networks. Its structural characteristics suggest interaction with catalytic residues, allosteric pockets and regulatory scaffolds, enabling modulation of phosphorylation circuits, second‑messenger systems (cAMP, Ca²⁺, IP₃), ROS generation, membrane polarization and metabolic‑flux channeling.
Depending on biological context, NALORPHINE may alter mitochondrial membrane potential, redox buffering capacity, calcium sequestration, cytoskeletal integrity, vesicle trafficking efficiency and transcription‑factor activation, resulting in broad mechanistic adaptability across experimental systems.
Benefits and Advantages
This compound is highly valued in advanced biochemical and pharmacological research frameworks, including:
- High‑resolution receptor–ligand mapping and affinity prediction
- Enzyme‑kinetic profiling and catalytic‑pathway deconstruction
- Mitochondrial‑stress testing, ATP‑flux analysis and ROS‑equilibrium studies
- Integrated multi‑omics research: transcriptomics, metabolomics, proteomics, phosphoproteomics
- Cytoskeletal modelling involving actin/tubulin regulation
- Apoptosis, autophagy, necroptosis and ferroptosis signalling investigations
- Structure–activity relationship (SAR) exploration and molecular optimisation
- Pharmacodynamic simulations for mechanistic threshold and dose‑response studies
Side Effects and Risks
Possible laboratory‑observed risks include:
- Redox imbalance with elevated ROS levels
- Mitochondrial overactivation or respiratory‑chain suppression
- Ion‑channel dysregulation affecting Na⁺/K⁺/Ca²⁺ flow
- Cross‑activation or inhibition of unintended receptor systems
- Cytoskeletal destabilisation and impaired membrane integrity
- Dose‑dependent cytotoxicity or induction of apoptotic/autophagic pathways
- Transcriptional instability and activation of inflammatory cascades (NF‑κB, JNK, p38)
Strict biosafety handling, controlled dosing and regulated environmental conditions are required for all experimental use. Not intended for human or veterinary application.
Datasheet
| Molecular Formula | C19H21NO3 |
|---|---|
| Molecular Weight | 311.4 g/mol |
| CAS Number | 62-67-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | ODORLESS; WHITE OR PRACTICALLY WHITE, CRYSTALLINE POWDER; INSOL IN CHLOROFORM & ETHER; SOL IN DIL ALKALI HYDROXIDE /NALORPHINE HYDROCHLORIDE/ |
| Purity | Purity information is available upon request (COA). |
| Synonym | Nalorphine; N-Allylnormorphine; Nalorfina; Allylnormorphine; 62-67-9 |
| IUPAC/Chemical Name | (4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol |
| InChl Key | UIQMVEYFGZJHCZ-SSTWWWIQSA-N |
| InChl Code | InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1 |
| References |
3D Conformer.
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