MESALAZINE
Mesalazine is an antiinflammatory agent acting in the colon by inhibiting prostaglandin and leukotriene pathways, used in ulcerative colitis. Benefits include mucosal healing and reduced flare frequency. Side effects include nausea, headache, and rare kidney effects. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
MESALAZINE displays a broad and multiaxis biochemical interaction profile characterised by modulation of enzymatic networks, receptormediated signalling, intracellular ion regulation, mitochondrial bioenergetics and transcriptional pathway governance. Its structural features suggest interactions with catalytic and regulatory proteins, leading to changes in phosphorylation cycles, metabolic flux, mitochondrial redox balance, calciumsignalling behaviour and stressresponse activation. Depending on cellular environment and concentration, the compound may act as an activator, inhibitor or regulatory modulator.
Benefits and Advantages
This compound supports a wide range of , including:
- Receptorligand affinity profiling and bindingsite mapping
- Enzymecascade modelling and catalyticdomain interaction studies
- Mitochondrialfunction assays, oxidativestress evaluation and metabolicflux tracking
- Transcriptomic, proteomic and metabolomic investigation for pathway mapping
- Apoptosis / autophagy pathway research and cellularstress modelling
- Highresolution mechanismofaction studies and SAR exploration
Side Effects and Risks
Potential risks include oxidative imbalance, mitochondrial overload, ionchannel dysregulation, receptor crosstalk, cytoskeletal disruption and dosedependent cytotoxicity. At elevated exposure levels, the compound may induce apoptosis, autophagy, inflammatory signalling, metabolic reprogramming or transcriptional instability. Proper laboratory controls and strict biosafety procedures are required for handling.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C7H7NO3 |
|---|---|
| Molecular Weight | 153.14 g/mol |
| CAS Number | 89-57-6 |
| Storage Condition | Commercially available oral mesalamine delayed-release tablets should be stored at a controlled room temperature of 20-25 °C, while the commercially available oral extended-release capsules should be stored at 25 °C but may be exposed to temperatures ranging from 15-30 °C. |
| Solubility | less than 1 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | 5-Aminosalicylic acid; mesalamine; Mesalazine; 89-57-6; 5-Amino-2-hydroxybenzoic acid |
| IUPAC/Chemical Name | 5-amino-2-hydroxybenzoic acid |
| InChl Key | KBOPZPXVLCULAV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11) |
| References |
3D Conformer.
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