MEGESTROL ACETATE
Megestrol acetate is a synthetic progestin with appetitestimulating and antineoplastic properties, used in cancerrelated cachexia and breast or endometrial cancers. Benefits include weight gain and symptom relief. Side effects include thromboembolic risk, edema, adrenal suppression, and mood changes. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
MEGESTROL ACETATE exhibits a multilayered biochemical interaction profile involving modulation of enzyme cascades, receptorregulated signalling, mitochondrial bioenergetics, redoxstate equilibrium, membranepotential dynamics and transcriptionfactor activation. Depending on concentration and cellular context, the compound can influence phosphorylation cycles, alter calcium signalling thresholds, disrupt or stabilise cytoskeletal structures, and reprogram metabolic flux pathways.
Benefits and Advantages
This compound is widely used in advanced mechanistic research, including:
- Receptorligand interaction analysis and allostericbinding studies
- Enzymekinetic mapping and catalyticdomain investigation
- Mitochondrialfunction, ROSbalance and redoxmodulation assays
- Transcriptomic, proteomic and metabolomic profiling
- Cellularstress signalling, apoptosis/autophagy modelling and membranedynamics studies
- Pharmacodynamic simulation, SAR evaluation and earlystage compound screening
Side Effects and Risks
Possible risks include mitochondrial overload, oxidativestress imbalance, ionchannel disruption, metabolic pathway misregulation, receptor crosstalk, and dosedependent cytotoxicity. At higher exposure, apoptosis, autophagy, transcriptional destabilisation or inflammationpathway activation may occur. Use only with strict laboratory safety procedures.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C24H32O4 |
|---|---|
| Molecular Weight | 384.5 g/mol |
| CAS Number | 595-33-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | MEGESTROL ACETATE; 595-33-5; Megace; Megestryl acetate; Niagestin |
| IUPAC/Chemical Name | [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate |
| InChl Key | RQZAXGRLVPAYTJ-GQFGMJRRSA-N |
| InChl Code | InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1 |
| References |
3D Conformer.
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