LEUCOSON

Leucovorin supports folate metabolism and rescues healthy cells from methotrexate toxicity. Benefits include reduced chemotherapy toxicity. Side effects include nausea and allergic reactions. Only GMP materials will be supplied, logistics all according to GDP.

SKU: 58afac83493a Category: Tag:

Product Description


Mechanism of Action

LEUCOSON demonstrates a highcomplexity biochemical profile involving modulation of receptor systems, enzymeregulated metabolic pathways, mitochondrial performance, intracellular ion dynamics and transcriptionlevel regulation. Its structural properties support binding to catalytic and regulatory protein domains, altering phosphorylation cascades, redoxstate equilibrium, cellular stressresponse thresholds and mitochondrial signalling output.

The molecule may influence calcium flux, ATP turnover, ROSantioxidant balance, cytoskeletal organisation and membranepotential stability depending on the biological system and concentration applied.

Benefits and Advantages

Widely applied in mechanistic and pharmacodynamic research, including:

  • Receptorligand interaction analysis and affinity profiling
  • Enzymekinetic and catalyticpathway investigations
  • Mitochondrialfunction, metabolicflux and oxidativestress studies
  • Multiomics research: transcriptomics, proteomics and metabolomics
  • Cellstress signalling, apoptosis/autophagy modelling and cytoskeletaldynamics mapping
  • Preclinical screening, SAR modelling and comparative mechanistic benchmarking

Side Effects and Risks

Potential risks include oxidative imbalance, mitochondrial strain, unintended receptor crossactivation, ionchannel perturbation, metabolic rewiring, and dosedependent cytotoxicity. High exposure may induce apoptosis, autophagy, inflammatory signalling or transcriptional destabilisation. Strict laboratory safety protocols and controlled handling conditions are required.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C14H17NO4S

Molecular Weight

295.36 g/mol

CAS Number

1950-36-3

Storage Condition

Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.

Solubility

Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance.

Purity

Purity information is available upon request (COA).

Synonym

Leucogen; 1950-36-3; Leyk; NSC-400257; 5ZB58O726V

IUPAC/Chemical Name

2-(2-ethoxy-2-oxo-1-phenylethyl)-1,3-thiazolidine-4-carboxylic acid

InChl Key

XDBMTQVSHNQIFU-UHFFFAOYSA-N

InChl Code

InChI=1S/C14H17NO4S/c1-2-19-14(18)11(9-6-4-3-5-7-9)12-15-10(8-20-12)13(16)17/h3-7,10-12,15H,2,8H2,1H3,(H,16,17)

References

https://pubchem.ncbi.nlm.nih.gov/compound/101105;

3D Conformer.

(Click, turn or enlarge)

Download our GMP API Product List.

MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.

Download