HYDROXYZINE HCL
Hydroxyzine HCl is an antihistamine with anxiolytic and sedative effects by blocking H1 receptors. Side effects include drowsiness, dry mouth, and impaired coordination. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
HYDROXYZINE HCL exhibits a multi-dimensional biochemical activity profile that affects cellular regulation at enzyme, receptor, and transcriptional levels. Its molecular interactions can alter phosphorylation cycles, modulate ionic homeostasis, influence mitochondrial respiration, and adjust redox-signaling pathways. Structural properties suggest specific affinity for regulatory proteins, enabling modulation of metabolic flux and cellular response thresholds.
Benefits and Advantages
This compound is suited for high-resolution mechanistic research, multiomics integration studies, receptor-binding experiments, enzyme-pathway mapping, and advanced pharmacodynamic modelling. It supports ROS-regulation assays, signalling-cascade analysis, cytoskeletaldynamics research, and metabolic adaptation models. Due to predictable biochemical behaviour, it is often used as a comparative reference in pathwayperturbation studies.
- Useful in mechanistic pharmacology and biochemical modelling
- Applicable in oxidative-stress, mitochondrial-function and signalling studies
- Reliable for transcriptional and proteomic profiling
- Supports SAR (structureactivity relationship) investigations
Side Effects and Risks
Potential risks include mitochondrial overload, ROS imbalance, inadvertent receptor crosstalk, disruption of ion-channel dynamics, and dose-dependent cytotoxicity. High exposure may trigger apoptosis, autophagy, or cellular stress-response activation. Controlled handling conditions and biosafety protocols are required for laboratory use.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C21H27ClN2O2·HCl |
|---|---|
| Molecular Weight | 447.8 g/mol |
| CAS Number | 2192-20-3 |
| Storage Condition | Commercially available preparations of hydroxyzine should be stored in tight, light-resistant containers at a temperature less than 40 °C, preferably at 15 – 30 °C; freezing of the oral solution, oral suspension, or injection should be avoided. |
| Solubility | Crystals; MP 193 °C; Bitter taste. Solubility in mg/mL: water <700; chloroform 60; acetone 2; ether <0.1. Solutions are unstable to intense UV light. /Hydroxyzine dihydrochloride/ |
| Purity | Purity information is available upon request (COA). |
| Synonym | Hydroxyzine dihydrochloride; 2192-20-3; Hydroxyzine hydrochloride; Orgatrax; Hydroxyzine Hcl |
| IUPAC/Chemical Name | 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride |
| InChl Key | ANOMHKZSQFYSBR-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H |
| References |
3D Conformer.
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