About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
HYDROCHLOROTHIAZIDE exhibits a complex biochemical signature characterized by multipathway modulation involving receptor interaction, enzymatic pathway alteration, mitochondrial signalling influence and transcriptionlevel regulation. Its molecular structure suggests affinity for catalytic domains and regulatory protein surfaces, enabling modulation of phosphorylation cycles, redox equilibrium, metabolic flux and intracellular secondmessenger dynamics. Through these combined mechanisms, the compound can shift cellular homeostasis, alter stressresponse thresholds, and influence adaptive pathway activation.
Benefits and Advantages
This compound is used extensively in advanced biochemical modelling, mechanistic pathway validation, receptorligand binding experiments, ROSmodulation studies, mitochondrialfunction assays, kinase/phosphatase cascade mapping and earlystage pharmacodynamic screening. Its stable and reproducible activity allows highfidelity comparative assays, multiomics profiling (proteomic, metabolomic and transcriptomic), and SAR exploration.
- Supports highresolution mechanistic research
- Useful for controlled pathway perturbation models
- Applicable in metabolic and endocrine modelling
- Valuable for cytotoxicity, redox and stressresponse assays
Side Effects and Risks
Potential risks include mitochondrial overload, ROS imbalance, offtarget receptor or enzyme interactions, modulation of cytoskeletal integrity, calciumflux disruption and dosedependent apoptotic or autophagic signalling. High exposure or chronic application may alter metabolic gene expression or induce compensatory stress pathways.
Use only in controlled laboratory environments following appropriate biosafety and chemicalhandling protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C7H8ClN3O4S2 |
|---|---|
| Molecular Weight | 297.7 g/mol |
| CAS Number | 58-93-5 |
| Storage Condition | PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for … expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties …) that bears appropriate label. An inventory … should be kept, showing quantity of carcinogen & date it was acquired … Facilities for dispensing … should be contiguous to storage area. /Chemical Carcinogens/ |
| Solubility | less than 0.1 mg/mL at 72.5 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | hydrochlorothiazide; 58-93-5; Esidrix; HCTZ; Hypothiazide |
| IUPAC/Chemical Name | 6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide |
| InChl Key | JZUFKLXOESDKRF-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13) |
| References |
3D Conformer.
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