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Product Description
Mechanism of Action
HYDROCHLOROTHIAZIDE (ID 26368) exhibits a complex biochemical signature characterized by multi‑pathway modulation involving receptor interaction, enzymatic pathway alteration, mitochondrial signalling influence and transcription‑level regulation. Its molecular structure suggests affinity for catalytic domains and regulatory protein surfaces, enabling modulation of phosphorylation cycles, redox equilibrium, metabolic flux and intracellular second‑messenger dynamics. Through these combined mechanisms, the compound can shift cellular homeostasis, alter stress‑response thresholds, and influence adaptive pathway activation.
Benefits and Advantages
This compound is used extensively in advanced biochemical modelling, mechanistic pathway validation, receptor‑ligand binding experiments, ROS‑modulation studies, mitochondrial‑function assays, kinase/phosphatase cascade mapping and early‑stage pharmacodynamic screening. Its stable and reproducible activity allows high‑fidelity comparative assays, multi‑omics profiling (proteomic, metabolomic and transcriptomic), and SAR exploration.
- Supports high‑resolution mechanistic research
- Useful for controlled pathway perturbation models
- Applicable in metabolic and endocrine modelling
- Valuable for cytotoxicity, redox and stress‑response assays
Side Effects and Risks
Potential risks include mitochondrial overload, ROS imbalance, off‑target receptor or enzyme interactions, modulation of cytoskeletal integrity, calcium‑flux disruption and dose‑dependent apoptotic or autophagic signalling. High exposure or chronic application may alter metabolic gene expression or induce compensatory stress pathways.
Use only in controlled laboratory environments following appropriate biosafety and chemical‑handling protocols.
Datasheet
| Molecular Formula | C7H8ClN3O4S2 |
|---|---|
| Molecular Weight | 297.7 g/mol |
| CAS Number | 58-93-5 |
| Storage Condition | PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for … expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties …) that bears appropriate label. An inventory … should be kept, showing quantity of carcinogen & date it was acquired … Facilities for dispensing … should be contiguous to storage area. /Chemical Carcinogens/ |
| Solubility | less than 0.1 mg/mL at 72.5 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | hydrochlorothiazide; 58-93-5; Esidrix; HCTZ; Hypothiazide |
| IUPAC/Chemical Name | 6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide |
| InChl Key | JZUFKLXOESDKRF-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13) |
| References |
3D Conformer.
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